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Adrian Lupescu

Institute of Physiology -Karls-University of Tuebingen, Germany, Tuebingen, Germany

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Born: 1978

Interests: fluorescence optics - cytosolic Ca2+ activity - pH activity

Details:
Awards:


2008: Carl Liebermeister Preis die Medizinische Fakultät und das Interdisziplinäre Zentrum für Klinische Forschung ,Eberhard-Karls-Universitätmedizin Tübingen

2001 3th PLACE at the Scientific Conference for Medical Students and Young
Doctors -Craiova,1-3 June 2001 with Conduita clinicii ORL Craiova in
rezolvarea corpilor straini traheobronsici - Adrian Lupescu , Elena Ionita

2002 HONORABLE MENTION at the 4th International Medical Conference for
Students and Young Doctors, Sibiu, 6-9 November 2003 with Investigation of the
Effect of Herbal Plant Extracts on the Lymphocyte Proliferation - Adrian Lupescu,
Torsten Boehler, Hans-H. Neumayer

2005 EXCELLENCY PRICE at MARISIENSIS - the conference for Medical Students and
Young Doctors - Tirgu Mures, 5-8 May 2005, Stimulation of Ca2+ Entry by
Parvovirus B19 Protein VP1 - Adrian Lupescu, P. A. Lang, H. Kaiser, R. Kandolf, T.
Bock, F. Lang


Publications:

1. Impaired mast cell activation in gene-targeted mice lacking the serum- and glucocorticoid-inducible kinase SGK1.
Sobiesiak M, Shumilina E, Lam RS, Wölbing F, Matzner N, Kaesler S, Zemtsova IM, Lupescu A, Zahir N, Kuhl D, Schaller M, Biedermann T, Lang F.
J Immunol. 2009 Oct 1;183(7):4395-402. Epub 2009 Sep 11.PMID: 19748978 [PubMed - indexed for MEDLINE]Free Article
.
2. Inhibition of Na+/H+ exchanger activity by parvovirus B19 protein NS1.
Lupescu A, Geiger C, Zahir N, Aberle S, Lang PA, Kramer S, Wesselborg S, Kandolf R, Foller M, Lang F, Bock CT.
Cell Physiol Biochem. 2009;23(1-3):211-20. Epub 2009 Feb 18.PMID: 19255516 [PubMed - indexed for MEDLINE]

3. EGR-1 is regulated by N-methyl-D-aspartate-receptor stimulation and associated with patient survival in human high grade astrocytomas.Mittelbronn M, Harter P, Warth A, Lupescu A, Schilbach K, Vollmann H, Capper D, Goeppert B, Frei K, Bertalanffy H, Weller M, Meyermann R, Lang F, Simon P.
Brain Pathol. 2009 Apr;19(2):195-204. Epub 2008 May 16.PMID: 18489490 [PubMed - indexed for MEDLINE]

4. Association of SGK1 gene polymorphisms with type 2 diabetes.
Schwab M, Lupescu A, Mota M, Mota E, Frey A, Simon P, Mertens PR, Floege J, Luft F, Asante-Poku S, Schaeffeler E, Lang F.
Cell Physiol Biochem. 2008;21(1-3):151-60. Epub 2008 Jan 16.PMID: 18209482 [PubMed - indexed for MEDLINE

5. Tabebuia avellanedae extracts inhibit IL-2-independent T-lymphocyte activation and proliferation.
Böhler T, Nolting J, Gurragchaa P, Lupescu A, Neumayer HH, Budde K, Kamar N, Klupp J.
Transpl Immunol. 2008 Feb;18(4):319-23. Epub 2007 Sep 4.PMID: 18158117 [PubMed - indexed for MEDLINE]

6. Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide.
Lang PA, Schenck M, Nicolay JP, Becker JU, Kempe DS, Lupescu A, Koka S, Eisele K, Klarl BA, Rübben H, Schmid KW, Mann K, Hildenbrand S, Hefter H, Huber SM, Wieder T, Erhardt A, Häussinger D, Gulbins E, Lang F.
Nat Med. 2007 Feb;13(2):164-70. Epub 2007 Jan 28.PMID: 17259995 [PubMed - indexed for MEDLINE]

7. Mitochondria are not required for death receptor-mediated cytosolic acidification during apoptosis.
Waibel M, Kramer S, Lauber K, Lupescu A, Manns J, Schulze-Osthoff K, Lang F, Wesselborg S.
Apoptosis. 2007 Mar;12(3):623-30. Epub 2006 Dec 29.PMID: 17195091 [PubMed - indexed for MEDLINE]

8. Phospholipase A2 activity-dependent stimulation of Ca2+ entry by human parvovirus B19 capsid protein VP1.
Lupescu A, Bock CT, Lang PA, Aberle S, Kaiser H, Kandolf R, Lang F.
J Virol. 2006 Nov;80(22):11370-80. Epub 2006 Sep 6.PMID: 16956939 [PubMed - indexed for MEDLINE]Free PMC Article

9. Human parvovirus B19: a new emerging pathogen of inflammatory cardiomyopathy.
Bock CT, Klingel K, Aberle S, Duechting A, Lupescu A, Lang F, Kandolf R.
J Vet Med B Infect Dis Vet Public Health. 2005 Sep-Oct;52(7-8):340-3. Review.PMID: 16316397 [PubMed - indexed for MEDLINE

10. Glycogen metabolism in rat ependymal primary cultures: regulation by serotonin.
Verleysdonk S, Kistner S, Pfeiffer-Guglielmi B, Wellard J, Lupescu A, Laske J, Lang F, Rapp M, Hamprecht B.
Brain Res. 2005 Oct 26;1060(1-2):89-99. Epub 2005 Oct 3.PMID: 16202983 [PubMed - indexed for MEDLINE]

11. Serum- and glucocorticoid-inducible kinase 1 (SGK1) mediates glucocorticoid-induced inhibition of insulin secretion.
Ullrich S, Berchtold S, Ranta F, Seebohm G, Henke G, Lupescu A, Mack AF, Chao CM, Su J, Nitschke R, Alexander D, Friedrich B, Wulff P, Kuhl D, Lang F.
Diabetes. 2005 Apr;54(4):1090-9.PMID: 15793248 [PubMed - indexed for MEDLINE]Free Article

12. Deranged Kv channel regulation in fibroblasts from mice lacking the serum and glucocorticoid inducible kinase SGK1.
Shumilina E, Lampert A, Lupescu A, Myssina S, Strutz-Seebohm N, Henke G, Grahammer F, Wulff P, Kuhl D, Lang F.
J Cell Physiol. 2005 Jul;204(1):87-98.PMID: 15605386 [PubMed - indexed for MEDLINE]Related citations

13. 14. Apigenin-induced suicidal erythrocyte death. Lupescu A, Zbidah M,Jilani K, Fajol A, Michael D, Qadri SM, Lang F.
J Agric Food Chem. 2012 Jan 11;60(1):533-8. Epub 2011 Dec 23.PMID:22132906 [PubMed - as supplied by publisher]

14. 13.Hexavalent chromium-induced erythrocyte membrane phospholipid asymmetry.
Lupescu A, Jilani K, Zelenak C, Zbidah M, Qadri SM, Lang F.Biometals. 2011 Nov 13. [Epub ahead of print]
PMID:22080200 [PubMed - as supplied by publisher]



Abstracts:

1) Histopatological methods used in diagnosis of Helicobacter Pylori - 9 th International Conference for Students and Young Doctors, Gdansk, Poland, 10-12 May 2001

2) Posttraumatic chronic frontal sinusitis with subperiostal manifestation and retention of external parts - 12 th European Students Conference for Medical Students and Young Doctors at Charite, the Medical Faculty of Humboldt University in Berlin, 20-25 Nov.2001

3) Atitudini terapeutice diferentiate in infertilitatea endocrina feminina (Differentiated therapeutic approaches in female endocrine infertility) - MEDIS 2002, The 6 th International Medical Students and Young Doctors Meeting, 16-18 th May 2002

4) Asocierea dintre infectia herpetica si eritemul polimorf (Association between the herpetic infection and Polymorphous Erithema) - MEDIS 2002, The 6 th International Medical Students and Young Doctors Meeting, 16-18 th May 2002

5) Sinuzita frontala cronica posttraumatica cu manifestari subperiostale si retentie de corpi straini (Posttraumatic Chronic frontal sinusitis with subperiostale manifestation and retention foreign corps) - Scientific Conference for Medical Students and Young Doctors -Craiova, 24-26 May 2002

6) Eritemul polimorf - locul infectiei herpetice in etiopatologia bolii (Polymorphous Erithema- The significance of Herpetic Infection in the Etiopathology of this disease) - Scientific Conference for Medical Students and Young Doctors -Craiova, 24-26 May 2002


7) Efectele Imunomodulatorii a Extraselor din 11 Plante Naturale ( Immunomodulatory
Effects of 11 Herbal Plants ), Scientific Conference for Medical Students and Young
Doctors -Craiova, 6-8 June 2003

8) Studiul Potentialelor Evocate Vizuale in Scleroza Multipla (The study of evocation visual potentials in Multiple Sclerosis) - Scientific Conference for Medical Students and Young Doctors -Craiova,1-3 June 2001

9) Case presentation- BRUGADA Syndrome - MEDIS 2001 - The 5 th International Congress for Students and Young Doctors -Timisoara, 4-6 May 2001

10) Sindromul malformativ in disginezia gonadica (Malformative syndrome in
gonadal disginesis)- MEDIS 2002, The 6 th International Medical Students and
Young Doctors Meeting, 16-18 th May 2002

11) Klippel - Trenaunay Syndrome - Case presentation - MEDIS 2002, The 6 th
International Medical Students and Young Doctors Meeting, 16-18 th May 2002


12) Stimulation of Ca2+ Entry by Parvovirus B19 Protein VP1 - The 84th Annual Meeting of the
German Physiological Society Goettingen, Germany, March 6-9, 2005

13) Inhibition of Na+/H+ exchanger activity by Parvovirus B19 Protein NS1- The 84th
Annual Meeting of the German Physiological Society in München, Germany,
March 26-29, 2006

Selected publications:
• Lupescu A, Jilani K, Zelenak C, Zbidah M, Qadri SM, Lang F. . Hexavalent chromium-induced erythrocyte membrane phospholipid asymmetry. . , 2011.
• Lupescu A, Zbidah M, Jilani K, Fajol A, Michael D, Qadri SM, Lang F. . Apigenin-induced suicidal erythrocyte death. . , 2011.
• Böhler T, Nolting J, Gurragchaa P, Lupescu A, Neumayer HH, Budde K, Kamar N, Klupp J. . Tabebuia avellanedae extracts inhibit IL-2-independent T-lymphocyte activation and proliferation. Transpl Immunol. 2008 Feb; 18(4):319-23. Epub 2007 Sep 4, 2008.
• Schwab M, Lupescu A, Mota M, Mota E, Frey A, Simon P, Mertens PR, Floege J, Luft F, Asante-Poku S, Schaeffeler E, Lang F. . Association of SGK1 Gene Polymorphisms with Type 2 Diabetes. Cell Physiol Biochem. 2008; 21(1-3):151-60. Epub 2008 Jan 16, 2008.
• Philipp A Lang, Marcus Schenck, Jan P Nicolay, Jan Ulrich Becker, Daniela S Kempe, Adrian Lupescu, Saisudha Koka, Kerstin Eisele, Barbara A Klarl, Herbert Ru¨bben, Kurt W Schmid, Klaus Mann, Sibylle Hildenbrand, Harald Hefter, Stephan M Huber, Thomas Wieder. Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide. Nature Medicine, 2007.
• Waibel M, Kramer S, Lauber K, Lupescu A, Manns J, Schulze-Osthoff K, Lang F, Wesselborg S. . Mitochondria are not required for death receptor-mediated cytosolic acidification during apoptosis. . Apoptosis, 2006.
• Lupescu A, Bock CT, Lang PA, Aberle S, Kaiser H, Kandolf R, Lang F. . Phospholipase A2-Activity Dependent Stimulation of Ca2+ Entry by Human Parvovirus B19 Capsid Protein VP1. Journal of Virology, 2006.
• C. -Thomas Bock, Karin Klingel, Susanne Aberle, Anja Duechting, Adrian Lupescu, Florian Lang and Reinhard Kandolf. Human parvovirus B19: A new emerging pathogen of inflammatory. JVB 52, 2005.
• Verleysdonk S, Kistner S, Pfeiffer-Guglielmi B, Wellard J, Lupescu A, Laske J, Lang F, Rapp M, Hamprecht B. . Glycogen metabolism in rat ependymal primary cultures: Regulation by serotonin. . Brain Research, 2005.
• Susanne Ullrich, Susanne Berchtold, Felicia Ranta, Guiscard Seebohm, Guido Henke, Adrian Lupescu, Andreas F. Mack, Cho-Ming Chao, Jiping Su, Roland Nitschke, Dorothea Alexander, Björn Friedrich, Peer Wulff, Dietmar Kuhl, Florian Lang. SGK1 mediated glucocorticoid induced inhibition of insulin secretion. Diabetes, 54, pp. 1090-1099, 2005.
• Shumilina E, Lampert A, Lupescu A, Myssina S, Strutz-Seebohm N, Henke G, Grahammer F, Wulff P, Kuhl D, Lang F. -Deranged Kv channel regulation in fibroblasts from mice lacking the serum and glucocorticoid inducible kinase SGK1. Journal of Cellular Physiology in 2004 Dec 16, in press 2005, pp. Pages 87 -, 2005.


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