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Ioan Ovidiu Sirbu

UMF Timisoara, Timisoara, Romania

Institution web page: http://www.umft.ro
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Born: 1969

Interests: developmental biology, patterning, retinoic acid, microRNA

Details:
University of Medicine and Pharmacy "V. Babes" Timisoara, Biochemistry Department, Romania, 2013-
Embryology and Teratology laboratory - Timisoara, Romania (1996-1999)
University of Medicine and Pharmacy "V. Babes" Timisoara, Romania (1999-2001)
Pasteur Institute, Paris, Franta (Oct. 2001-Nov. 2002)
Burnham Institute, La Jolla, CA, USA (Jan 2003-May 2006)
Ulm University, Biochemistry and Molecular Biology department, Ulm, Germany (Sept 2006-2012)

ResearcherID: F-1841-2010

Selected publications:
• Tata PR, Tata NR, Kühl M, Sirbu IO. . Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC. . Nucleic Acid Research, 2011.
• Woltering JM, Vonk FJ, Müller H, Bardine N, Tuduce IL, de Bakker MA, Knöchel W, Sirbu IO, Durston AJ, Richardson MK. Axial patterning in snakes and caecilians: evidence for an alternative interpretation of the Hox code. Developmental Biology, 332, pp. 82-89, 2009.
• Sirbu IO, Pandur P. . Saving hearts through basic research. . Birth defects research. Part C, Embryo today : reviews, 87, pp. 273-283, 2009.
• Zhao X, Sirbu IO, Mic FA, Molotkova N, Molotkov A, Kumar S, Duester G. . Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning. Current Biology, 19, pp. 1050-1057, 2009.
• IO Sirbu, X Zhao, Duester G. Retinoic acid controls heart anteroposterior patterning by down-regulating Isl1 through the Fgf8 pathway. . Developmental Dynamics, 237(6), pp. 1627-35, 2008.
• Ioan Ovidiu Sirbu, Gregg Duester. Retinoic-acid signalling in node ectoderm and posterior neural plate directs left-right patterning of somitic mesoderm. . Nature Cell Biology, 8(3), pp. 271-277, 2006.
• Natalia Molotkova, Andrei Molotkov, I. Ovidiu Sirbu and Gregg Duester. Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation. . Mechanisms of Development, 122(2), pp. 145-155, 2005.
• Ioan Ovidiu Sirbu, Lionel Gresh, Jacqueline Barra and Gregg Duester. Shifting boundaries of retinoic acid activity control hindbrain segmental gene expression. Development, 132(11), pp. 2611-22, 2005.
• Mic FA, Sirbu IO, Duester G. Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation. . Journal of Biological Chemistry, 279(25), pp. 26698-706, 2004.
• A. Anghel, C. Marian, Mara Pitulescu, Alina Daba, I. O. Sirbu, V. Rusu and B. Budowle. Population genetic study of eight short tandem repeat loci CSF1PO, TPOX, TH01, F13A01, FESFPS, vWA, F13B and LPL in the Western Romanian population. . Forensic Science International, 131(2-3), pp. 218-219, 2003.
• Cristina Gagyi, Nadia Bucurenci, Ovidiu Sirbu, Gilles Labesse, Mihaela Ionescu, Augustin Ofiteru, Liliane Assairi, Stéphanie Landais, Antoine Danchin, Octavian Barzu and Anne-Marie Gilles. UMP kinase from the Gram-positive bacterium Bacillus subtilis is strongly dependent on GTP for optimal activity. European Journal of Biochemistry, 270, pp. 3196-3204, 2003.


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