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>> Românã

Stefan Eugen Szedlacsek

Laboratorul de Enzimologie - Institutul de Biochimie al Academiei Romane, Bucuresti, Romania

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Born: 1952

Interests: enzymology, receptors, . protein structure, signal transduction, enzyme kinetics

I am primarily interested in understanding the relationship between the structure and function of enzymes involved in signal transduction processes. Specifically, I am studying together with my team, the protein tyrosine phosphatases: their structural and kinetic characteristics, their substrate specificities - all of them in connection with the physiological role they play in signalling processes.

ResearcherID: F-1830-2010

Selected publications:
• Balasu MC, Spiridon LN, Miron S, Craescu CT, Scheidig AJ, Petrescu AJ, Szedlacsek SE. Interface analysis of the complex between ERK2 and PTP-SL. PLoS ONE, 4(5), p. e5432, 2009.
• Pascaru M, Tanase C, Vacaru AM, Boeti P, Neagu E, Popescu I, Szedlacsek SE. . ANALYSIS OF MOLECULAR DETERMINANTS OF PRL-3. . J Cell Mol Med, 13(9B), pp. 3141-50, 2008.
• Tabernero L, Aricescu AR, Jones EY, Szedlacsek SE. . Protein tyrosine phosphatases: structure-function relationships. FEBS J. , 275(5), pp. 867-882, 2008.
• Köhn M, Gutierrez-Rodriguez M, Jonkheijm P, Wetzel S, Wacker R, Schroeder H, Prinz H, Niemeyer CM, Breinbauer R, Szedlacsek SE, Waldmann H. . A microarray strategy for mapping the substrate specificity of protein tyrosine phosphatase. . Angew Chem Int Ed Engl. , 46(40), pp. 7700-3, 2007.
• Vlad MO, Morán F, Popa VT, Szedlacsek SE, Ross J. . Functional, fractal nonlinear response with application to rate processes with memory, allometry, and population genetics. Proc Natl Acad Sci U S A, 104(12), pp. 4798-803, 2007.
• Dursina B, Reents R, Delon C, Wu Y, Kulharia M, Thutewohl M, Veligodsky A, Kalinin A, Evstifeev V, Ciobanu D, Szedlacsek SE, Waldmann H, Goody RS, Alexandrov K. Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids. J. Am. Chem. Soc. , 128, pp. 2822-35, 2006.
• Vlad MO, Szedlacsek SE, Pourmand N, Cavalli-Sforza LL, Oefner P, Ross J. . Fisher' s theorems for multivariable, time- and space-dependent systems, with applications in population genetics and chemical kinetics. . Proc Natl Acad Sci U S A. , 102, pp. 9848-53, 2005.
• Cismasiu VB, Denes SA, Reilander H, Michel H, Szedlacsek SE. . The MAM (meprin/A5-protein/PTPmu) domain is a homophilic binding site promoting the lateral dimerization of receptor-like protein-tyrosine phosphatase mu. . J Biol Chem. , 279, pp. 26922-31, 2004.
• Aricescu AR, Fulga TA, Cismasiu V, Goody RS, Szedlacsek SE. . Intramolecular interactions in protein tyrosine phosphatase RPTPmu: kinetic evidence. . Biochem. Biophys. Res. Commun. , 280(1), pp. 319-27, 2001.
• Szedlacsek SE, Aricescu AR, Fulga TA, Renault L, Scheidig AJ. . Crystal structure of PTP-SL/PTPBR7 catalytic domain: implications for MAP kinase regulation. . J. Mol. Biol. , 311(3), pp. 557-68, 2001.
• Baici A, Szedlacsek SE, Fruh H, Michel BA. . pH-dependent hysteretic behaviour of human myeloblastin (leucocyte proteinase 3). Biochem. J. , 317 ( Pt 3), pp. 901-5, 1996.
• Szedlacsek SE, Aricescu AR, Havsteen BH. . Time-dependent control of metabolic systems by external effectors. J. Theor. Biol. , 182(3), pp. 341-50, 1996.
• Szedlacsek SE, Duggleby RG. Kinetics of slow and tight-binding inhibitors. Methods Enzymol. , 249, pp. 144-80, 1995.


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