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Grigore DAMIAN

" Babes-Bolyai" University, Faculty of Physics, Department of Biomedical Physics, Molecular Spectroscopy and Teoretical Physics, Cluj-Napoca, Romania

Institution web page: http://www.phys.ubbcluj.ro
Personal web page: http://www.phys.ubbcluj.ro/~grigore.damian
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Born: 1957

Interests: EPR and FTIR spectroscopy in biomolecular studies

Details:
EDUCATION
“Stefan cel Mare” High School, Tg.Neamt, Neamt (1976)
University Bucharest, Faculty of Physics (BS), Bucharest (1981)
University Bucharest, Faculty of Physics (MS) Bucharest (1982)
Ph.D. in physics, "Babes-Bolyai" University, Faculty of Physics, Cluj-Napoca (1997)

ACTUAL POSITION: Professor, "Babes-Bolyai" University, Cluj-Napoca, Faculty of Physics

DIDACTIC ACTIVITY: courses:

Atomic and Nuclear Physics
Atomic and Molecular Processes at liquid -solid Interfaces
Radioactive sources
Nuclear analytical methods
Physical Methods in Medical Therapy
Atom and Molecular Physics

PUBLICATIONS:

-over 50 papers in international ISI journals
-over 50 papers in national journals
-over 60 scientific communications
-5 books

MEMBER OF SCIENTIFIC SOCIETIES:

-Romanian Physical Society
-Balcanic Physical Society
-European Physical Society
-Romanian Biophysical Society
-Romanian Biomaterial Society

INTERNATIONAL GRANTS:

•TEMPUS grant, (1993), University of Groningen, Department of Chemistry, The Netherlands.
•Grant from "International Center for Academic Cooperation" for "Environmental Health", Prague, 1999
•Grant from European Commission and JOINT RESEARCH CENTRE, Institute for Transuranium Elements (Physical Protection Group), Karlsruhe, Germany, "Radioactivity - Radionuclides - Radiation 2nd Multi-Media Training Course with Nuclides.net", 2003
•FT-EPR Training Course, Bruker-Biospin, Karlsruhe, Germania, 2007


ORGANISATIONAL SKILLS AND COMPETENCES

•Director of "Free Radicals research Center" CNCSIS nr.65/2.06.2005
•Member of National Register of Evaluators (NRE)of The Romanian Agency for Quality Assurance in Higher Education
•Expert for research project funding by National Council of Scientific Research

RESEARCH

EPR and FTIR spectroscopy to investigate
- the effect of pharmaceutical stress testing (sterilization, oxidation and photolysis) on the drug substance and foods (free radicals formation, identification and determination of their structure).
- the conformational changes of secondary structure of proteins in different biochemical conditions and lyophilizations.
- utilization of spin labels and spin trap in the study of biological procesess

Selected publications:
• Bianca Muresan, Claudia Cimpoiu, Anamaria Hosu, Cristina Bischin, Emese Gal, Grigore Damian, Eva Fischer-Fodor, Radu Silaghi-Dumitrescu. Antioxidant content in Romanian, traditional distilled alcoholic beverages. Studia UBB, seria Chemia, LX, 2, Tom II, pp. 355-370, 2015.
• Augustin C Mot, Cristina Bischin, Bianca Muresan, Marcel Parvu, Grigore Damian, Laurian Vlase, Radu Silaghi-Dumitrescu. Antioxidant activity evaluation by physiologically relevant assays based on haemoglobin peroxidase activity and cytochrome c-induced oxidation of liposomes. Natural Product Research, DOI:10.1080/14786419.2015.1054824, pp. 1-5, 2015.
• Augustin C. Mot, Cristina Bischin, Grigore Damian, Radu Silaghi-Dumitrescu. Antioxidant Activity Evaluation Involving Hemoglobin-Related Free Radical Reactivity. In Donald Armstrong (ed.), Methods in Molecular Biology, " Advanced Protocols in Oxidative Stress III" , Volume 1208, pp. 247-255. Spriger, 2015.
• Hathazi, D., Mot, A. C., Vaida, A., Scurtu, F., Lupan, I., Fischer-Fodor, E., Damian, G., Kurtz, D. M., Silaghi-Dumitrescu, R. . Oxidative protection of hemoglobin and hemerythrin by cross-linking with a nonheme iron peroxidase: Potentially improved oxygen carriers for use in blood substitutes. Biomacromolecules, 15(5), pp. 1920-1927, 2014.
• Laurian Vlase, Daniela Benedec, Daniela Hanganu, Grigore Damian, Ioan Csillag, Bogdan Sevastre, Augustin C. Mot, Radu Silaghi-Dumitrescu and Ioan Tilea. Evaluation of Antioxidant and Antimicrobial Activities and Phenolic Profile for Hyssopus officinalis, Ocimum basilicum and Teucrium chamaedrys. Molecules, 19, pp. 5490-5507, 2014.
• Istvan Mihaly Takacs, Augustin Mot, Radu Silaghi-Dumitrescu, Grigore Damian. EPR investigation of libration motion of spin labeled hemerythrin. Journal of Molecular Structure, http://dx.doi.org/10.1016/j.molstruc.2014.01.074, 2014.
• Luiza Gaina, Ioana Torje, Emese Gal, Alexandru Lupan, Cristina Bischin, Radu Silaghi-Dumitrescu, Grigore Damian, Peter Lönnecke, Castelia Cristea, Luminita Silaghi-Dumitrescu. Microwave assisted synthesis, photophysical and redox properties of (phenothiazinyl)vinyl-pyridinium dyes. Dyes and Pigments, 102, pp. 315-325, 2014.
• Mot, A. C., Coman, C., Miron, C., Damian, G., Sarbu, C., Silaghi-Dumitrescu, R. . An assay for pro-oxidant reactivity based on phenoxyl radicals generated by laccase. Food Chemistry , 143, pp. 214-222 , 2014.
• Pompei Bolfa, Raluca Vidrighinescu, Andrei Petruta, Dan Dezmirean, Laura Stan, Laurian Vlase, Grigore Damian, Cornel Catoi, Adriana Filip, Simona Clichici. Photoprotective effects of Romanian propolis on skin of mice exposed to UVB irradiation. Food and Chemical Toxicology, http://dx.doi.org/10.1016/j.fct.2013.08.078, 2013.
• Delia Marcu , Grigore Damian, Constantin Cosma and Victoria Cristea. Gamma radiation effects on seed germination, growth and pigment content, and ESR study of induced free radicals in maize (Zea mays). Journal of Biological Physics, 39(4), pp. 625-634, 2013.
• Benedec, D., Vlase, L., Oniga, I., Mot, A. C., Damian, G., Hanganu, D., Duma, M., Silaghi-Dumitrescu, R. . Polyphenolic composition, antioxidant and antibacterial activities for two Romanian subspecies of Achillea distans Waldst. et Kit. ex Willd. . Molecules, 18 (8) , pp. 8725-8739, 2013.
• Istvan Mihaly Takacs, Augustin Mot, Radu Silaghi-Dumitrescu, Grigore Damian . Site directed spin labeling Hemerythrin and hemoglobin. Studia UBB, seria Chemia, 58(2), pp. 61-69, 2013.
• Jean de Dieu Tamokou, Jean Rodolphe Chouna, Eva Fischer-Fodor, Gabriela Chereches, Otilia Barbos, Grigore Damian, Daniela Benedec, Mihaela Duma, Alango Pépin Nkeng Efouet, Hippolyte Kamdem Wabo, Jules Roger Kuiate, Augustin Mot, Radu Silaghi-Dumitrescu. Anticancer and Antimicrobial Activities of Some Antioxidant-Rich Cameroonian Medicinal Plants. PLos ONE, 8(2), e55880, doi:10.1371/journal.pone.0055880, pp. 1-14, 2013.
• Todica, M. , Udrescu, L., Damian, G., Astilean, S. Spectroscopic investigation of PVA-TIO2 membranes gamma irradiated. Journal of Molecular Structure, 10.1016/j.molstruc.2012.12.006, pp. 328-330, 2013.
• C. Ivascu, I. B. Cozar, L. Daraban, G. Damian. Spectroscopic investigation of P2O5-CdO-Li2O glass system. Journal of Non-Crystalline Solids, 359, pp. 60-64, 2013.
• Augustin C. Mot, Marcel Parvu, Grigore Damian, Zsuzsanna Darula, Katalin F. Medzihradszky, Balazs Brem, Radu Silaghi-Dumitrescu. A “yellow” laccase with “blue” spectroscopic features, from Sclerotinia sclerotiorum. Process Biochemistry, 47( 6), p. 968–975, 2012.
• Daniela Cioloboc, Adrian-Raul Tomsa, Grigore Damian, Radu Silaghi-Dumitrescu. High spin to low spin change induced by reductive chemistry with iron-substituted Dawson polyoxometalate. Inorganic Chemistry Communications, doi: 10.1016/j.inoche.2012.02.019, 2012.
• Augustin C. Mot, Sergei A. Syrbu, Sergei V. Makarov, Grigore Damian, Radu Silaghi-Dumitrescu. Axial ligation in water-soluble copper porphyrinates: contrasts between EPR and UV–vis. Inorganic Chemistry Communications, 18, pp. 1-3, 2012.
• Laura Bolojan, István Mihály Takács, Vasile Miclaus and Grigore Damian. EPR study of superoxide radicals from potassium superoxide. Applied Magnetic Resonance, 42( 3), pp. 333-341, 2012.
• Nicoleta Simona Vedeanu, Dana Alina Magdas, Laura Bolojan and Grigore Damian. Antioxidant potential and authenticity of some commercial fruit juices studied by EPR and IRMS. Chemical Papers, 66(6), pp. 612-616, 2012.
• DANA ALINA MAGDAS, NICOLETA SIMONA VEDEANU, LAURA BOLOJAN, ROMULUS PUSCAS, GRIGORE DAMIAN. Comparative study between single strenght juice and commercial natural juices by IRMS and EPR. Studia Universitatis Babes-Bolyai Chemia, LVI, 2 , pp. 19 - 27, 2011.
• DOINA PRODAN, LAURA SILAGHI-DUMITRESCU, PREJMEAN CRISTINA, RADU SILAGHI-DUMITRESCU, LAURA BOLOJAN, G. DAMIAN. Evaluation of Free Radical Concentration in Some New Dental Composite Materials by ESR Spectroscopy. Studia Univrsitatis Babes–-Bolyai, Chemia, Volume 56 (LVI), pp. 201-206, 2011.
• Bianca Iacob, Florina Deac, Daniela Cioloboc, Grigore Damian, Radu Silaghi-Dumitrescu. Hemoglobin-albumin crosslinked copolymers: reduced prooxidant reactivity. Artificial Cells, Blood Substitutes and Biotechnology, doi:10.3109/10731199.2011.563362, 2011.
• Cristina Bischin, Florina Deac, Radu Silaghi-Dumitrescu, Jonathan A. R. Worrall, Badri S. Rajagopal, Grigore Damian & Chris E. Cooper . Ascorbate peroxidase activity of cytochrome c. Free Radical Research, 45(4), pp. 439-444, 2011.
• Deac Florina, Iacob Bianca, Eva Fischer-Fodor, Grigore Damian, Radu Silaghi-Dumitrescu. Derivatization of hemoglobin with periodate-generated reticulation agents: evaluation of oxidative reactivity for potential blood substitutes. The Journal of Biochemistry, 149 (1), pp. 75-82, 2011.
• Anamaria Hosu, Claudia Cimpoiu, Vasile Miclaus, Grigore Damian, Iirina Tarsiche, Nnastasia Pop. Influence of Intermittent Heating during Maceration on the Antioxidant Capacity of some Grape Seeds and Skins. Not. Bot. Hort. Agrobot. , 38 (1) , pp. 41-43, 2010.
• Augustin Mot, Kis Zoltan, Dimitri A. Svistunenko, Grigore Damian, Radu Silaghi-Dumitrescu, Sergei V. Makarov. Super-reduced iron under physiologically-relevant conditions. Dalton Trans, 39, pp. 1464-1466, 2010.
• L. I. SABAU, G. DAMIAN, D. DAICOVICIU, A. MURESAN, D. POSTESCU, D. MIHU, C. MIHU, N. COSTIN, C. ALB. In vivo study regarding antioxidant effect of red grape polyphenol extract using biochemical and FT-IR methods. Journal of Optoelectronics and Advanced Materials-Symposia, 2(1), pp. 44-49, 2010.
• V. MICLAUS, C. CIMPOIU, A-M. HOSU, L. I. SABAU, G. DAMIAN. Synthesis and characterization of spin labeled nicotinic acid derivatives in some biological environments. Journal of Optoelectronics and Advanced Materials-Symposia, 2,1, pp. 31-33, 2010.
• Adrian-Raul Tomsa, Daniela Cioloboc, Ana Maria Todea, Radu Silaghi-Dumitrescu, Grigore Damian, and Mariana Rusu. SYNTHESIS, SPECTROSCOPIC AND ELECTROCHEMICAL CHARACTERIZATION OF A NEW CHROMIUM (III) SUBSTITUTED DAWSON POLYOXOMETALAT. STUDIA UNIVERSITATIS BABES-BOLYAI, CHEMIA, LIV, 4, pp. 95-105, 2009.
• Augustin-Catalin Mot, Grigore Damian, Costel Sarbu, Radu Silaghi-Dumitrescu. Redox reactivity in propolis: direct detection of free radicals in basic medium and interaction with hemoglobin. Redox Report, Vol 14 No 6, pp. 267-274, 2009.
• Dina Petrisor, Grigore Damian, Simion Simon, Ana Maria Hosu, Vasile Miclaus. Antioxidant activity, of some types of white wines and juices investigated by EPR spectroscopy. Modern Physics Letters B, 22(27), pp. 2689-2698, 2008.
• Dina Petrisor, Grigore Damian, Simion Simon. Gamma-irradiated Extravit M nutritive supplement studied by Electron Paramagnetic Resonance Spectroscopy. Radiation Physics and Chemistry, 77, p. 463–466, 2008.
• C. Cimpoiu, A. Hosu, G. Damian, V. Miclaus. EPR and spectrophotometric investigation of the antioxidant capacity of some romanian grapes and wines. In Eur. Biophys. J. , 36 (Suppl 1):S51–S248, p. 171. Springer, 2007.
• Grigore Damian, Dina Petrisor, Vasile Miclaus. Free Radicals Detection by ESR PBN Spin-Trap Technique. Journal of Optoelectronics and Advanced Materials, 9(4), pp. 1010-1013, 2007.
• Cavalu, S. Cinta Pinzaru, N. Peica, G. Damian, W. Kiefer. Adsorption behavior of hyaluronidase onto silver nanoparticles and PMMA bone substitute. Journal of Optoelectronics and Advanced Materials, 9(3), pp. 689-692, 2007.
• I. Bratu, M. T. Cotisel, G. Damian, A. Mocanu. Secondary structure analysis of barley aleurone holoprotein by FTIR spectroscopy. Journal of Optoelectronics and Advanced Materials, 9(3), pp. 675-677, 2007.
• D. Petrisor, G. Damian, S. Simon, G. Schmutzer, A. Hosu, V. Miclaus. , EPR investigation of antioxidant characteristics of some irradiated natural extracts. Journal of Optoelectronics and Advanced Materials, 9(3), pp. 656-659, 2007.
• I. D. Postescu, C. Tatomir, G. Chereches, I. Brie, G. Damian, D. Petrisor, A-M. Hosu, V. Miclaus, A. Pop. Spectroscopic characterization of some grape extracts with potential role in tumor growth inhibition. Journal of Optoelectronics and Advanced Materials, 9(3), pp. 564-567, 2007.
• G. Damian, G. Schmutzer, D. Petrisor. Investigation of light-induced free radicals in nifedipine. Journal of Optoelectronics and Advanced Materials, 9(3), pp. 680-683, 2007.
• S. Cavalu, S. Cinta Pinzaru, G. Damian. Structural information, unfolding and aggregation in globular proteins, by Raman, SERS, FT-IR and complementary EPR spectroscopy. In R. K. Soni, et al (eds. ), Proceedings ICOPVS 2006, International Conference on Perspectives in Vibrational Spectroscopy, Meerut, India, p. 3, 2006.
• O. Cozar, D. A. Magdas, L. Nasdala, I. Ardelean and G. Damian. Raman spectroscopic study of some lead phosphate glasses with tungsten ions. Journal of Non-Crystalline Solids, 352, pp. 3121-3125, 2006.
• G. Damian, S. Cavalu. Comparative study of amide I and III bands of ovalbumin and bovine serum albumin by FTIR Spectroscopy. Asian Journal of Chemistry-Asian Chemistry Letters, 9, 1-2, pp. 3-8, 2005.
• Cimpoiu, C., Casoni, D., Hosu, A., Miclaus, V, . Damian, G., Hodisan, T. Separation and Identification of Eight Hydrophilic Vitamins Using New TLC Method and Raman Spectroscopy. J. Liq. Chromatogr. Related Techn, 28 (16), pp. 2551-2559, 2005.
• T. Jurca, S. Cavalu, G. Damian, F. Banica. ATR FT-IR studies of transitional nicotinamide. Rev. Chim, 55, 7, pp. 492-495, 2004.
• G. Damian, O. Cozar, V. Miclaus. Investigation of some adsorbed copper(II) complexes on NaY zeolite by EPR spectroscopy. Romanian Journal of Physics, 48,I, pp. 465-473, 2003.
• C. Cimpoiu, V. Micaus, G. Damian, M. Puia, D. Casoni, C. Bele, T. Hodisan. Identification of new phatalazine derivatives by HPTLC-FTIR and characterization of their separation using some molecular properties. J. Liq. Chromatography & Related Technologies, 26,16, pp. 2687-2696, 2003.
• S. Cavalu, G. Damian. Rotational correlation times of 3-carbamoyl-2, 2, 5, 5-tetramethyl-3-pyrrolin-1-yloxy spin label with respect to heme and nonheme proteins. Biomacromolecules, 4,6, pp. 1630-1635, 2003.
• G. Damian. EPR investigation of gamma-irradiated anti-emetic drugs. Talanta, 60, pp. 923-927, 2003.
• C. Cimpoiu, V. Miclaus, G. Damian and S. Hodisan. Separation and identification of some nitroxidic derivatives of nicotinic acid and isonicotinic acid by high performance thin layer chromatography(HTPLC)coupled with electronic paramagnetic resonance(EPR). J. Liq. Chromatography & Related Technologies, 25,12, pp. 1515-1520, 2002.
• S. Cavalu, G. Damian, M. Dansoreanu. EPR study of noncovalent spin labelled serum albumin and haemoglobin. Biophysical Chemistry, 99:2, pp. 181-188, 2002.
• O. Cozar, L. David, V. Chis, G. Damian, M. Todica, C. Agut. IR and ESR studies on some dimeric copper(II) complexes. J. of Mol. Structure, 563-564, pp. 371-375, 2001.
• E. Forizs, L. David, O. Cozar, V. Chis and G. Damian. IR and ESR Studies on Copper(II) complexes of Theophylline compexes containing mono or bidentate ligands. J. of Mol. Stucture, 482-483, pp. 143-147, 1999.
• M. Todica, G. Damian, O. Cozar and L. David. NMR and ESR Study of local Dynamics in some polyisoprene solutions. J. of Mol. Stucture, 482-483, pp. 353-357, 1999.
• G. Damian, O. Cozar, M. Todica, L. David, D. Ristoiu. EPR Study of some Copper Heterocyclic Azomethine complexes adsorbed on X and Y zeolites. J. of Mol. Stucture, 482-483, pp. 287-289, 1999.
• G. Damian, V. Miclaus, V. Znamirovschi, O. Cozar, L. David. The dynamics of nitroxide radicals in chloroform and deuterated chloroform solutions adsorbed on zeolites. Progress in Catalysis, 7,2, pp. 61-66, 1998.
• G. Damian, O. Cozar, V. Miclaus, V. Znamirovschi, V. Chis, L. David. ESR study of the dynamics of adsorbed nitroxide radicals on porous surfaces in dehydration process. Colloids and Surfaces A, 137, 1, pp. 1-7, 1998.
• O. Cozar, V. Chis, L. David, G. Damian, I. Barbur. ESR investigation of gamma-irradiated Aspirin. J. of Radioanalytical and Nuclear Chemistry, 220, p. 241, 1997.
• O. Cozar, L. David, V. Chis, E. Foris, G. Damian, I. Bratu. Local structure analysis of Cu(II)-diazepam complexes by ESR spectroscopy. Fresenius J. Anal. Chem, 355, p. 701, 1996.
• O. Cozar, L. David, V. Chis, C. Cosma, V. Znamirovschi, G. Damian, I. Bratu, Gh. Bora. ESR study of some solvent effects on Cu(II)-Aspirine Complex. Apll. Magn. Reson, 8, p. 235, 1995.


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