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Daniela-Annenelie Bota

University of California Irvine, Irvine, USA

Institution web page: www.uci.edu
Personal web page: http://www.healthcare.uci.edu/findadoctor/bio.aspx?hsid=500001305
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Born: 1973

Interests: neuro-oncology, cancer stem cells, mitochondrial proteolysis, free radicals research

Details:
MD - Carol Davila University of Medicine-Bucharest, 1997
PhD - University of Southern California, Department of Molecular Biology, 2002
Residency-Neurology: University of Kansas Medical Center: 2002-2006
Neuro-oncology Fellowship: Duke University Brain Tumor Center: 2006-2007
Assistant Professor of Neurology, University of California Irvine: since 2007

Publications:
1. Daniela A Bota, Henry S. Friedman Interstitial Chemotherapy with Biodegradable BCNU (GliadelR) Wafers in the Treatment of Malignant Gliomas, Therapeutics and Clinical Risk Management, 3(5): 707-715. 2007
2. D.A. Bota, MD, PhD; G. Gronseth, MD; M. Glantz, MD. Practice Parameter: Radiation therapy and Chemotherapy for Low-Grade Glioma (An Evidence-Based Review). Report of the Quality Standards Subcommittee of the American Academy of Neurology (accepted for publication in Neurology)
3. Bota RG, M.D., Munro JS, M.D., Ricci WF, M.D., Bota DA, M.D., Ph.D. "Dynamics of insight in the prodrome of schizophrenia" CNS Spectrum 11(5):355-62. 2006
4. Bota, D.A., Ngo, J.K., and Davies, K.J.A., 2005. Downregulation of the Human Lon Protease Impairs Mitochondrial Structure, Function and Replication, and Causes Cell Death. Free Radic. Biol. Med. 38, 665-77
5. Bota, D.A., and Davies, K.J.A., 2002. Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nature Cell Biology 4, 674-680.
6. Bota, D.A., Van Remmen, H. and Davies, K.J.A., 2002. Modulation of Lon Protease Activity and Aconitase Turnover during Aging and Oxidative Stress. FEBS Letters 532, 103-106.
7. Bota, D.A., 2002. Importance of the Lon protease in Mitochondrial Protein Turnover and Cellular Bioenergetics during Oxidative Stress and Aging. PhD Dissertation Defense, University of Southern California, Department of Molecular and Computational Biology
8. Bota, D. A., and Davies, K.J.A., 2001. Protein Degradation in Mitochondria: Implications for Oxidative Stress, Aging and Disease. A novel etiological classification of mitochondrial proteolysis disorders. Mitochondrion 1, 33-49.


Selected publications:
• Bota DA, Van Remmen H, Davies KJ. . Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress. . FEBS Lett, 532(1-2), pp. 103-106, 2002.
• Daniela A. Bota, Kelvin J. A. Davies. Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nature Cell Biology, 4, pp. 674-680, 2002.
• Daniela A. Bota, Kelvin J. A. Davies. Protein Degradation in Mitochondria: Implications for Oxidative Stress, Aging and Disease. Mitochondrion, 1, pp. 33-49, 2001.


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