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Iuliana Ristea Popescu

University of Kentucky, Lexington, USA

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Born: 1976

Interests: diabetes, islet biology, nuclear receptors, metabolism, obesity,

PhD - Biopharmaceutical Sciences, Lille 2 University France, European Genomic Institute of Diabetes (EGID), INSERM U1011 Lille, France - Lab. of Nuclear Receptors, Cardiovascular Diseases and Diabetes
***Implication of the nuclear receptor FXR in glucose metabolism and diabetes. Study of its expression, regulation and function in the endocrine pancreas.
- Master in Biophysics & Cellular Biotechnologies, Faculty of Medicine, Bucharest
- Faculty of Pharmacy, UMF Bucharest

Work experience in research:
- 2014, Post-doc, Pharmacology & Nutritional Sciences, University of Kentucky, Lexington, USA. (Diabetic cardiomyopathy)
- 2011 - 2013, Post-doc / visiting researcher, Lab. of Experimental Hormonology - ULB Brussels, Belgium (Glucose transporters in diabetic islets)
- 2010 - 2011,Post-doc, Lab. of General Histology & Neuropathology - ULB Brussels, Belgium (stem cell therapy in ALS)

Involvement in research projects:
- NIH Project on Cardiac remodelling of diabetic heart (UK 2014, USA)
- EU FP7 Project VIBRANT (In Vivo Imaging of Beta-cell Receptors by Applied Nano Technology), ULB Brussels (2011 - 2013)
- Thierry Latran Foundation / Fondation de France - Human motor neurons derived from induced pluripotent stem cells (iPSc),a new approach for modeling and treating human ALS" (2010-2011), Brussels
- EU FP6 Project HEPADIP (Hepatic and Adipose Tissue and Functions in the Metabolic Syndrome), 2006-2009, INSERM 1011, France
- Agence Nationale de Recherche (ANR, France) (The role of nuclear receptor FXR in glucose homeostasis), 2006-2009, INSERM 1011, France

Selected publications:
• 2. Bonner C, Kerr-Conte J, Gmyr V, Queniat G, Moerman E, Thévenet J, Beaucamps C, Delalleau N, Popescu I, Malaisse WJ, Sener A, Deprez B, Abderrahmani A, Staels B, Pattou F. Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. Nature Med. , Apr 20. doi: 10.1038/nm.3828 , 2015.
• Caroline. Bonner, Iuliana Popescu, Gurvan Queniat, Valery Gmyr, Ericka Moerman, Cedric Beaucamps, Nathalie Delalleau, Julien Thevenet, William J. Malaisse, Abdullah Sener, Amar Abderrahmani, Bart Staels, Julie Kerr-Conte, Francois Pattou. . The glucose transporter SGLT 2 is expressed in human pancreatic alpha cells and is required for proper control of glucagon secretion in type 2 diabetes. In DIABETES, 63 (Supplement 1). 2014.
• S. Cetik, E. Hupkens, WJ Malaisse, A Sener, I. Popescu . Expression and localization of glucose transporters in the submandibular salivary glands. CELL PHYSIOL BIOCHEM , 2014.
• Awada A, Nicaise C, Ena S, Schandéné L, Rasschaert J, Popescu I, Gangji V, Soyfoo MS. Potential involvement of the IL-33/ST2 axis in the pathogenesis of primary Sjögren’s syndrome. . ANN RHEUM DIS, 2014.
• I. Popescu, P. Demetter, P. Loi, W. J. Malaisse and A. Sener. Species-specific differences in islet expression pattern of glucose transporters. In Metabolic and Functional Research on Diabetes (Online) , Vol 6. 2013.
• Virreira M, Popescu I, Gillet C, Zhang Y, Thimm J, Thiem J, WJ Malaisse, A. Sener. Immunocytochemistry of GLUT2, uptake of fluorescent streptozotocin analogs and phosphorylation of D-glucose in INS1E cells. MOL MED REP, 2013.
• I. Popescu, C. Nicaise, S Liu, G Bisch, S Kinipenberg, V Daubie, D Bohl, R Pochet. Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of ALS. STEM CELL Transl Med, 2013.
• I Popescu. PPARs as metabolic integrators in pancreatic beta-cells. New challenges for the therapy of type 2 diabetes . Studia Univ Arad, 2011.
• I Popescu. Signaling through bile acids – the impact on their own metabolism and lipid homeostasis . MET FUNCT RES IN DIAB , 2011.
• J. Prawitt, M. Abdelkarim, J. Stroeve, I. Popescu, H. Duez, V. R. Velagapudi, J. Dumont, E. Bouchaert, T. H. Van Dijk, A. Lucas, E. Dorchies, M. Daoudi, FJ. Gonzalez, M. Oresic, B. Cariou, F. Kuipers, S. Caron, B. Staels. Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity. DIABETES, 60(7), 2011.
• I Ristea Popescu, A. Helleboid-Chapman, A. Lucas, B. Vandewalle, J. Kerr Conte, J. Dumont, E. Bouchaert, S. Caron, F. Pattou, B. Staels. The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity, . FEBS Letters , 2010.


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