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Liviu Constantin Ciobanu

Centre de Recherche en Endocrinologie Moléculaire et Oncologie, Sainte Foy, Québec, Canada

Institution web page: http://www.crchul.ulaval.ca
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Born: 1970

Interests: organic chemistry, solid phase and combinatorial chemistry

Details:
Synthesis of steroidal and nonsteroidal compounds as potential inhibitors of steroidogenic enzymes involved in hormone-dependent diseases such as breast and prostate cancers. Combinatorial and solid-phase synthetic methodologies applicable in steroid chemistry.

Selected publications:
• Ciobanu LC, Luu-The V, Poirier D. Nonsteroidal compounds designed to mimic potent steroid sulfatase inhibitors. J Steroid Biochem Mol Biol, Mar;80(3), pp. 339-353, 2002.
• Ciobanu LC, Boivin RP, Luu-The V, Poirier D. Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group. Eur J Med Chem, Jul-Aug;36(7-8):, pp. 659-671, 2001.
• Ciobanu LC, Maltais R, Poirier D. . The sulfamate functional group as a new anchor for solid-phase organic synthesis. Organic Letters, Feb 24 2(4), pp. 445-448, 2000.
• Ciobanu LC, Boivin RP, Luu-The V, Labrie F, Poirier D. . Potent inhibition of steroid sulfatase activity by 3-O-sulfamate 17alpha-benzyl(or 4' -tert-butylbenzyl)estra-1, 3, 5(10)-trienes: combination of two substituents at positions C3 and C17-alpha of estradiol. . J Med Chem. , Jun 17;42(12), pp. 2280-6, 1999.


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