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>> Românã
 
   
 

Mariana Constantinovici

Biotehnos, Otopeni, Romania

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Born: 1972

Interests: in vitro tests, drug development, biotechnologies

Details:
Laboratory experience in the field of enzymatic activity determinations, kinetic data gathering, statistical data analyses using dedicated soft programs and estimation of kinetic parameters (rate constants, activation energies);
Cellular biology techniques for handling, manipulation and drug testing on normal and dysplasic cell cultures;
Biochemical and toxicological in vitro characterization of compounds with pharmaceutical and dermatocosmetic potential; cellular and tissular therapies in pathological processes and adaptative mechanisms of human cells.

Selected publications:
• B. Dumitriu, L. Olariu, M. Constantinovici, L. Zglimbea, N. Rosoiu. Estrogen-like" effect of some phytocompounds from Trifolium pratense for modulation of dermal fibroblasts physiology. In FEBS Journal, 278, suppl. 1, p. 135. 2011.
• M. Constantinovici, L. Zglimbea, N. Dociu, A. Netoiu, L. Olariu. Evaluation of metabolic effects of two triterpenic derivates obtained from Salvia sp. on endothelial primary cell culture Huvec. In Tox. Let. , 196S. 2010.
• N. Rosoiu, R. Nita, D. Ene, M. Constantinovici, L. Olariu. 'In vitro and in vivo investigation of some bioactive extracts rich in glycosaminoglycans obtained from small sea fish. In FEBS Journal , 276 (Suppl.1), p. 340. 2009.


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