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Liliana Burlibasa

Universitatea Bucuresti, Bucuresti, Romania

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Born: 1973

Interests: epigenetics, genetics, developmental biology

Details:
- Study of molecular processes that control the spatio-temporal gene expression;
- Study of chromatin assembly and chromatin remodelling processes during cytodifferentaition
- Study of epigenetic mechanisms involved in gametogenesis, fertilization, IVF (In Vitro Fertilization) and ART (Assisted Reproductive Technologies)
- The identification of the epigenetic modifications (posttranslational modifications of core histones and DNA methylation) that occur at genome level and specifically, at the level of ribosomal genes promoter in different stages of cellular differentiation correlated with gene expression, using lower vertabrates as model organisms
- Using of ChIP assay, DNA co-precipitation and Histone Association Assay (HAA) in order to identify the association between transcriptional factors and some specific epigenetic changes and correlation with genes expression.
- Study of chromatin remodelling complexes in model organisms
- Study of mechanisms involved in genomic imprinting and the indentification of some new imprinted genes in mammals
- Study of genetic and epigenetic mechanisms involved in oral and maxillo-facial disorders.

Selected publications:
• Burlibasa L, Gavrila L. Developmental Epigenetics: Roles in Embryonic Development . In Nutrition in Epigenetics. 2011.
• Burlibasa L. Analisys of DNA looped domains organization during Triturus cristatus spermatogenesis . Zygote, 2011.
• Burlibasa L., Cucu N., Gavrila L. Amphibians as model organisms for studying the dinamics of eukaryote genetic material architecture. Wild. Biol. Pract, 1(1), pp. 24-32, 2005.

Publications from the ISI database, indexed between 2002-2011, produced in Romania:
• Burlibasa, L; Gavrila, L, Molecular and ultrastructural studies of the sperm chromatin from Triturus cristatus. ZYGOTE, 13 (3), pp. 197-205, 2005.
• Burlibasa, L; Cucu, N; Gavrila, L, Dynamics of chromatin architecture during spermatogenesis of Triturus cristatus. CHROMOSOME RESEARCH, 13, p. 120, 2005.
• Burlibasa, L; Cucu, N; Motoc, R; Gavrila, L, Dynamics of chromatin structure and epigenetic changes in Triturus cristatus oogenesis. CHROMOSOME RESEARCH, 15, p. 21, 2007.
• Burlibasa, L; Cucu, N; Gavrila, L, An experimental approach to study the connection between DNA methylation and histone deacetylation during animal cytodifferentiation. CHROMOSOME RESEARCH, 15, p. 21, 2007.
• Cucu, N; Burlibasa, L; Matei, M; Turcu, E; Barsan, C; Prada, G; Radu, LG; Ciocoiu, F, Aging induced DNA hypomethylation effects on cell division and genome stability. CHROMOSOME RESEARCH, 15, pp. 67-68, 2007.
• Burlibasa, L; Cucu, N; Gavrila, L, Cellular and molecular characterization of epigenetic aspects associated with differentiation of crested newt oocytes. FEBS JOURNAL, 274, p. 75, 2007.
• Botezatu, A; Anton, G; Burlibasa, L; Cucu, N, Genomic instability in human breast tumors through hypermethylation of tumor suppressor promoter genes (ER alpha and RAR beta). FEBS JOURNAL, 274, p. 76, 2007.
• Gavrila, L; Burlibasa, L; Usurelu, MD; Radu, I; Magdalena, LM; Ardelean, A; Carabas, M, Chromosomal rearrangements in chironomus sp. As genosensors for monitoring environmental pollution. ROMANIAN BIOTECHNOLOGICAL LETTERS, 13 (5), pp. 3962-3969, 2008.
• Burlibasa, L; Zarnescu, O; Gavrila, L, In vivo effects of histone-deacetylase inhibitor trichostatin A (TSA) on chromatin dynamics during murine spermatogenesis. FEBS JOURNAL, 275, p. 102, 2008.
• Burlibasa, L; Zilrnescu, O; Cucu, N; Gavrila, L, Chromatin dynamics in Triturus cristatus oogenesis: an epigenetic approach. ZYGOTE, 16 (4), pp. 315-326, 2008.
• Cucu, N; Anton, G; Botezatu, A; Turcu, I; Spiru, L; Burlibasa, L, DNA HYPOMETHYLATING EFFECT OF A GERIATRIC PROTECTIVE DRUG AND CORRELATIONS WITH EPIGENETIC BIOMARKERS OF AGING. IUBMB LIFE, 61 (3), p. 361, 2009.
• Burlibasa, M; Burlibasa, L; Gavrila, LB; Gavrila, VR; Gavrila, L, microRNA a macro Revolution in Medical Biotechnologies. ROMANIAN BIOTECHNOLOGICAL LETTERS, 13 (6), pp. 3977-3983, 2008.
• Burlibasa, M; Tanase, G; Dumitriu, A; Bodnar, D; Bodnar, T; Mocuta, D; Burlibasa, L, Cytotoxicity and genotoxicity of commercial and novel binary titanium alloys. FEBS JOURNAL, 276, p. 303, 2009.
• Mocuta, D; Popovici, LR; Dumitriu, AS; Burlibasa, L; Ionescu, CA; Sfeatcu, R, LIFE QUALITY- CONDITION OF SOCIAL WELFARE. METALURGIA INTERNATIONAL, 14, pp. 62-64, 2009.
• Mocuta, D; Popovici, IA; Burlibasa, L; Cristache, G; Sfeatcu, R; Bodnar, T, IMPACT OF THE LIVING CONDITIONS ON POPULATION HEALTH. METALURGIA INTERNATIONAL, 14, pp. 17-19, 2009.
• Gavrila, L; Barbacar, N; Radu, I; Burlibasa, L; Magdalena, LM; Ardelean, A; Cimponeriu, GD; Popovici, E; Usurelu, MD; Macovei, I; Moranescu, F; Carabas, M, New aspects concerning the study of dipteran polytene chromosomal phenotype elements in Chironomus plumosus. ROMANIAN BIOTECHNOLOGICAL LETTERS, 14 (5), pp. 4625-4634, 2009.
• Bodnar, DC; Burlibasa, L; Varlan, C; Marcov, N; Georgescu, SR; Marcov, CE, MERCURY, BIOCOMPATIBILITY AND ITS IMPACT ON ENVIRONMENT. METALURGIA INTERNATIONAL, 14, pp. 95-100, 2009.
• Popescu, SM; Popescu, FD; Burlibasa, L, IN VITRO BIOCOMPATIBILITY OF ZIRCONIA. METALURGIA INTERNATIONAL, 15, pp. 14-25, 2010.
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