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Adriana Georgescu

Institutul de Biologie si Patologie Celulara ' Nicolae Simionescu' , Bucuresti, Romania

Institution web page: http://www.ad-astra.ro/adrianageorgescu
Personal web page: http://www.icbp.ro
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Born: 1971

Interests: pathophysiology of cardiovascular system, diabetes, atherosclerosis, obesity, circulating microparticles, endothelial progenitor cells; pharmacology; tissue engineering;

Details:
Personal data
Name: Adriana Georgescu, Ph.D., Biophysicist, Principal Investigator I
Born: January 22 th 1971, Calinesti-Topoloveni, Arges, Romania
Married in Bucharest, Romania
Address: Institute of Cellular Biology and Pathology 'Nicolae Simionescu', Bucharest, Romania
8, B.P. Hasdeu Street, P.O. Box 35-14, Ro-050568, Bucharest, Romania.
tel:(004021)3192737, fax:(004021)3194519, e-mail: adriana.georgescu@icbp.ro

Education, degrees and diplomas
1989 - Baccalaureate - 'Ion Mihalache' High School, Topoloveni, Arges, Romania
1995 - Bachelor's Degree in Physics. Faculty of Physics, University of Bucharest, Romania
1996 - Master's Degree in Biophysics, Faculty of Physics, University of Bucharest, Romania
2005 - Doctoral Degree, Summa Cum Laude, Natural Sciences: Biology Domain, Institute of Cellular Biology and Pathology 'Nicolae Simionescu', Bucharest, Romania- PhD supervisor Acad. Maya Simionescu
2010 - 2013 - Postdoctoral Research Fellow, ICBP 'Nicolae Simionescu', Bucharest, Romania and 'Petru Poni' Institute of Macromolecular Chemistry, Iasi, Romania, Research Domain: Biomaterials; subdomain: Materials for tissue engineering and implantology- postdoc supervisor Acad. Maya Simionescu
2014 (since January) – Habilitation Degree, The title of habilitation thesis: Vascular endothelial dysfunction: cardiovascular risk factors, new biomarkers and therapies.

Professional experience, former employers
1996 - 1999 - Research Assistant, Institute of Cellular Biology and Pathology (ICBP) 'N.Simionescu',
1999 - 2002 - Scientific Researcher, ICBP 'N. Simionescu',
2002 - 2006 - Principal Investigator III, ICBP 'N. Simionescu', Department: Vascular Dysfunction in Diabetes
1997 - 2004 - Ph.D. student, ICBP 'N. Simionescu',
2006 - 2012 - Principal Investigator II, ICBP ‘N. Simionescu’, Department: Pathophysiology and Pharmacology
2012 (since July) - Group leader, ICBP ‘N. Simionescu', Department of Pathophysiology and Pharmacology
2013 (since November) - Principal Investigator I, ICBP ‘N. Simionescu’, Department: Pathophysiology and Pharmacology
2014 (since January) - PhD supervisor, ICBP ‘N. Simionescu’

Training stages:
• 2001 (1 month) Frederic Alexander Universitat, Erlangen, Germany-Detection of DNA-bound advanced Glycation End-products - High performance liquid chromatography (HPLC) technique- Dr. Monika Pischetsrieder
• 2006 (1 month) Cardiovascular Research Center, INSERM - UMR970, Paris, France - Circulating Microparticle Isolation and Analysis - flow cytometry technique- Dr. Chantal M. Boulanger
• 2007 (2 months) Institute of Physiology and Biophysics, Aarhus University, Aarhus, Denmark–Downregulation of L-type calcium channel expression in rat small mesenteric arteries with siRNA transfection in vivo–wire, culture and pressure myograph techniques and in vivo measurements of intracellular calcium- Dr. Christian Aalkjaer
• 2011 (1 week)– Centre of Advanced Researchers for Bio-nanoconjugates and Biopolymers - ’Petru Poni’ Institute of Macromolecular Chemistry, Iasi, Romania - Scanning electron microscope tecnique – Dr. Mariana Pinteala
• 2012 (2 weeks)-University Medical Center, Dept. Pathology and Medical Biology, Groningen, Netherlands-Laser MicroDissection (LMD) System (on glomeruli and arteries), RNA isolation and integrity, cDNA synthesis and RT-qPCR - Dr. Grietje Molema
• 2012 (1 month) - Portuguese Institute of Oncology. Department of Angiogenesis, Lisbon, Portugal – HUVEC and HL60 cultures, microparticles isolation from cell cultures, miRNA isolation from MPs and RT-qPCR, Bioanalysis of miRNAs, fluorescence in situ hybridization- Dr. Sérgio Dias
• 2012 (1 month) - Queen’s University Belfast. Centre for Vision & Vascular Science Belfast (Northern Ireland, UK) - endothelial progenitor cell (EPC) isolation from peripheral blood; early and late EPC cultures; microparticles isolation from EPC cultures; confocal microscopy - Dr. Alan Stitt
• 2012 (1 month) - Center for Applied Medical Research (CIMA), University of Navarra, Division of Cardiovascular Sciences; Atherothrombosis, Atherosclerosis and Inflammation Department, Pamplona, Spain – thromboelastometry (ROTEM), mouse model of thromboembolic stroke, mouse tail bleeding model, flow cytometry, isolation and purification of microparticles from plasma of TAFI knockout mice after ischemic stroke model, fibrinolytic activity of microparticles, enzymatic kinetics, isolation of Human Umbilical Vein Endothelial Cells (HUVEC), immunohistochemistry for brain hemorrhage and infarct size. - Dr. Jose´ Antonio Páramo

Managerial competence: • Project manager for 11 national projects and 2 international grants; • Collaborator at 16 national projects and 4 international grants.

Scientific assignments:
- Scientific coordinator of Master thesis;
- Reviewer at scientific international journals: European Journal of Pharmacology; American Journal of Hypertension; Pharmaceutical Research; Scientia Pharmaceutica; Free Radical Research; Diabetes/Metabolism Research and Reviews; Cell Biochemistry and Biophysics; Acta Diabetologica; Central European Journal of Biology; Vascular Health and Risk Management (Dove Medical Press); Journal of Inflammation Research (Dove Medical Press); Diabetes, Metabolic Syndrome and Obesity(Dove Medical Press);Hypertension Research; Cardiovascular Diabetology; BMC Neurology; World Journal of Diabetes; Journal of Diabetes and Its Complications; Journal of Cardiology and Therapy; World Journal of Hematology; World Journal of Cardiology; Journal of Cardiovascular Pharmacology; Experimental Biology and Medicine; PLOS ONE.
- Expert evaluator for national and international grants: - National: #; Human Resources/projects: PD/TE; #; 'Joint research projects' - Collaboration Romania-France; #; Exploratory Workshops (WE);- International: #; Ministry of Science, Education and Sports (MSES) of the Republic of Croatia and the first Croatian Marie Curie FP7-PEOPLE-2011-COFUND program - NEWFELPRO; #; WHRI-ACADEMY fellowship programme : London, United Kingdom.
- Member in editorial board of international scientific journals: World Journal of Diabetes; World Journal of Hematology; Journal of Cardiology and Therapy; Journal of Stem Cells Research, Reviews & Reports; International Journal of Hematology Research; Frontiers in Cardiovascular Medicine: Molecular Cardiology; Pharmacologia.
- March 2011-September 2012) Expert Evaluator in Biology, Biochemistry and Pharmacy Commission of National Council for the Certify of Titles, Diplomas and University Certifications (CNATDCU);

Member in Scientific Societies:
•#; The Romanian Society for Cell Biology; #;Romanian Society for Developmental Biology; #; Romanian Society of Biochemistry; #;The Healthy Nutrition Foundation; #; The National Society for Regenerative Medicine and Surgery; #; Romanian Society of Hypertension; #; European Atherosclerosis Society; #;The Diabetes and Cardiovascular Disease EASD Study Group (D&CVD); #; European Vascular Biology Organisation (EVBO). #; European Society of Cardiology (ESC): Working Group on Atherosclerosis and Vascular Biology.

Research record
- Author and co-author at: 51 original papers in peered-reviewed journals (37 in ISI journals with impact factor (16 as first author and 9 as last author)); 17 abstracts in peered-reviewed journals; 2 book chapters, 2 books; 4 invited talks at prestigious Universities (Institutes); 14 invited talks at prestigious international conferences; 18 invited talks at prestigious national conferences; 18 national and 75 international poster communications.
- Project manager for 11 national projects and 2 international grants
- Collaborator of 16 national projects and 4 international grants
- Laureate of 16 Romanian and 6 International Awards
- Participant at 8 International Courses

List of publications:
Articles published in ISI indexed journals with impact factor
1. A. Georgescu, D. Popov. AGE-dependent accumulation of advanced glycation endproducts is accelerated in combined hyperlipidemia and hyperglycemia, a process attenuated by L-arginine. AGE: Journal of the American Aging Association (AGE AGEING), vol. 23, 33-40, 2000.- impact factor 5.83
2. G. Costache, D. Popov, A. Georgescu, M. Cenuse, V.V. Jinga, M. Simionescu. The effects of simultaneous hiperlipemia-hiperglycemia on the mesenteric resistance arteries, myocardium and kydney glomerili. J. Submicroscop. Cytol. Pathol,vol 32(1), 47-58, 2000. –impact factor 0.5
3. A. Georgescu, D. Popov, M. Simionescu. Mechanisms of impeded bradykinin-induced vasodilation in experimental hyperlipemia-hyperglycemia: contribution of nitric oxide and Ca2+ activated K+ channels. Fundamental and Clinical Pharmacology, vol. 15, 335-342, 2001.- impact factor 2.10
4. D. Popov, G. Costache, A. Georgescu, M. Enache. Beneficial effects of L-arginine supplementation in experimental hyperlipemia – hyperglycemia in the hamster. Cell and Tissue Research , 308 (1), 109-120, 2002. - impac factor 2.74
5. A. Georgescu, D. Popov, M. Capraru, M. Simionescu. Enoxaparin – a low molecular weight heparin, restores the altered vascular reactivity of resistance arteries in aged and aged-diabetic hamsters. Vascular Pharmacology,40, 167-174, 2003.- impact factor 2.31
6. A. Georgescu, D. Popov. The contractile response of the mesenteric resistance arteries to prostaglandin F2; effects of simultaneous hyperlipemia-diabetes. Fundamental and Clinical Pharmacology, vol 17, 683-689, 2003. –impact factor 2.10
7. M. Voinea, A Georgescu, A. Manea, E. Dragomir, I. Manduteanu, D. Popov, M. Simionescu Superoxide dismutase entrapped–liposomes restore the impaired endothelium-dependent relaxation of resistance arteries in experimental diabetes. European Journal of Pharmacology, vol 484(1), 111-118, 2004.- impact factor 2.78
8. D.L. Radu, A. Georgescu, C. Stavaru, A. Carale, D. Popov .Double transgenic mice with Type 1 diabetes mellitus develop somatic, metabolic and vascular disorders. J. Cell. Mol. Med., 8, 349-358, 2004.- impact factor 5.11
9. Adriana Georgescu, Florentina Pluteanu, Maria-Luisa Flonta, Elisabeta Badila, Maria Dorobantu, Doina Popov. The cellular mechanisms involved in the vasodilator effect of nebivolol on the renal artery. European Journal of Pharmacology, 508,159-166, 2005.- impact factor 2.78
10. Marc Schneider, Adriana Georgescu, Rose Kientsch-Engel, Peter Stahl, Doina Popov, Monika Pischetsrieder Detection of DNA-bound advanced Glycation End-products by immunoaffinity chromatography coupled to HPLC-Diode array detection. Molecular Nutrition & Food Research, 50, 424-429, 2006.- impact factor 4.3
11. Adriana Georgescu, Nicoleta Alexandru, Elena Constantinescu, Doina Popov. Effect of gap junction uncoupler heptanol on resistance arteries reactivity in experimental models of diabetes, hyperlipemia and hyperlipemia-Diabetes. Vascular Pharmacology 44, 513-518, 2006.- impact factor 2.31
12. Adriana Georgescu, Doina Popov, Emanuel Dragan, Elena Dragomir, Elisabeta Badila. Protective effects of nebivolol and reversal of endothelial dysfunction in diabetes associated with hypertension. “European Journal of Pharmacology”, 570,149-158, 2007.- impact factor 2.78
13. A. Georgescu, F. Pluteanu, M-L. Flonta, E. Badila, M. Dorobantu, D. Popov. Nebivolol induces the hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of the b2 – adrenoceptor. Pharmacology, 81:110-117, 2008.- impact factor 1.89
14. Adriana Georgescu, Nicoleta Alexandru, Doina Popov, Manuela Amuzescu, Eugen Andrei, Constantin Zamfir, Horia Maniu, Adrian Badila .Chronic venous insufficiency is associated with elevated level of circulating microparticles. Journal of Thrombosis and Haemostasis, 7 (9): 1566-1575, 2009.- impact factor 6.4
15. Popov Doina, Nemecz Miruna, Dumitrescu Madalina, Georgescu Adriana, Böhmer Frank D. Long-term high glucose concentration influences Akt, ERK1/2, and PTP1B protein expression in human aortic smooth muscle cells. Biochemical and Biophysical Research Communications, 388(1):51-55, 2009.- impact factor 2.64
16. Sadri Chahed, Aurélie S. Leroyer, Mounir Benzerroug, David Gaucher, Adriana Georgescu, Serge Picaud, Jean-Sébastien Silvestre, Alain Gaudric, Alain Tedgui, Pascale Massin, Chantal M. Boulanger. Increased vitreous shedding of microparticles in proliferative diabetic retinopathy stimulates endothelial proliferation. Diabetes, 59: 694-701, 2010.- impact factor 8.889
17. N. Alexandru, D. Popov, A. Georgescu. Intraplatelet oxidative/nitrative stress: inductors, consequences, and control. Trends Cardiovasc Med; 20: 232–238, 2010.- impact factor: 3.25.
18. Adriana Georgescu, Doina Popov, Anamaria Constantin, Miruna Nemecz, Nicoleta Alexandru, Daniel Cochior, Aura Tudor. Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with Type 2 diabetes. Clinical Science, 120(10): 463-472; 2011.- impact factor 4.85
19. Nicoleta Alexandru, Doina Popov, Emanuel Dragan, Eugen Andrei, Adriana Georgescu. Platelet activation in hypertension associated with hypercholesterolemia; effects of irbersartan. Journal of Thrombosis and Haemostasis, 9(1):173-84, 2011. - impact factor 6.4
20. Adriana Georgescu, Nicoleta Alexandru, Miruna Nemecz, Irina Titorencu, Doina Popov. Enoxaparin reduces adrenergic contraction of resistance arterioles in aging and in aging associated with diabetes via engagement of MAP kinase pathway. Blood Coagulation and Fibrinolysis, 22(4):310-316, 2011.- impact factor 1.4
21. Nicoleta Alexandru, Adriana Georgescu, Manuela Amuzescu, Constantin Zamfir, Adrian Badila, Doina Popov. Platelet reactivity in chronic venous insufficiency. Clinical Laboratory. 57(7-8): 527-534, 2011. - impact factor: 1.01
22. Marilena Lupu, Markus Khalil, Eugen Andrei, Florin Iordache, Kurt Pfannkuche, Klaus Neef, Adriana Georgescu, Cosmin Buzila, Konrad Brockmeier, Horia Maniu, Jürgen Hescheler. Integration properties of Wharton’s jelly-derived novel mesenchymal stem cells into ventricular slices of murine hearts. Cellular Physiology and Biochemistry, 28:63-76, 2011.- impact factor 3.58
23. Adriana Georgescu, Nicoleta Alexandru, Andrei Constantinescu, Irina Titorencu, Doina Popov. The promise of EPCs-based therapies on vascular dysfunction in diabetes. European Journal of Pharmacology. 669: 1-6, 2011 - impact factor 2.78
24. Adriana Georgescu. Vascular dysfunction in diabetes: the endothelial progenitor cells as new therapeutic strategy. World Journal of Diabetes, June 15; 2(6): 92-97, 2011.- ISI
25. I Titorencu, M. G. Albu, F. Anton, A. Georgescu, V. V. Jinga. Collagen – dexamethasone and collagen-D3 scaffolds for bone tissue engineering. Molecular Crystals and Liquid Crystals, 555: 1-10, 2012. - impact factor 0.502
26. Nicoleta Alexandru, Doina Popov, Adriana Georgescu. Platelet dysfunction in vascular pathologies and how can it be treated. Thrombosis Research, 129:116-126, 2012. – impact factor 2.44
27. Adriana Georgescu, Nicoleta Alexandru, Eugen Andrei, Irina Titorencu, Emanuel Dragan, Cristina Tarziu, Silviu Ghiorghe, Elisabeta Badila, Daniela Bartos, Doina Popov. Circulating microparticles and endothelial progenitor cells in atherosclerosis; pharmacological effects of irbesartan. Journal of Thrombosis and Haemostasis, 10: 680-691, 2012.- impact factor 6.4
28. Nicoleta Alexandru, Doina Popov, Emanuel Dragan, Eugen Andrei, Adriana Georgescu. Circulating endothelial progenitor cell and platelet microparticle impact on platelet activation in hypertension associated with hypercholesterolemia. PloS One, 8(1):e52058-e52068, 2013. - impact factor 4.092
29. Adriana Georgescu, Nicoleta Alexandru, Miruna Nemecz, Irina Titorencu, Doina Popov. Irbesartan administration therapeutically influences circulating endothelial progenitor cell and microparticle mobilization by involvement of pro-inflammatory cytokines. European Journal of Pharmacology, 711: 27-35, 2013. - impact factor 2.78
30. Bich-Hoai Thi Ton, Qingmin Chen, Gisela Gaina, Catalin Tucureanu, Adriana Georgescu, Carmen Strungaru, Maria-Luiza Flonta, Dinah Sah, Violeta Ristoiu. Activation profile of dorsal root ganglia Iba-1 (+) macrophages varies with the type of lesion in rats. Acta Histochemica, 115(8): 840-850, 2013. - impact factor 1,608
31. Nicoleta Alexandru, Adriana Georgescu. Circulating microparticles and microRNAs as players in atherosclerosis. World Journal of Hematology, 2(2): 16-19, 2013. - ISI
32. Elisabeta Badila, Ana Maria Daraban, Silviu Ghiorghe, Adriana Georgescu, Nicoleta Alexandru, Daniela Bartos, Cristina Tirziu. Rethinking cardiovascular therapy - the effect of irbesartan on circulating microparticles and endothelial progenitor cells in patients with hypertension and dyslipidemia. Farmacia, 62 (1): 93-106, 2014.- impact factor 1.25
33. Eugen Andrei, Nicoleta Alexandru, Emanuel Dragan, Adriana Georgescu. Flow cytometric analysis of circulating microparticles and endothelial progenitor cells in plasma; a research tool for atherosclerosis and therapy. Experimental and Clinical Cardiology, 20 (7): 1554-1563, 2014.- impact factor 1.10
34. Nicoleta Alexandru, Eugen Andrei, Emanuel Dragan, Adriana Georgescu. Interaction of platelets with endothelial progenitor cells in the experimental atherosclerosis; the role of transplanted endothelial progenitor cells and platelet microparticles. Biology of The Cell, 107: 189-204, 2015.- impact factor 3,87.
35. Elisabeta Badila, Ana Maria Daraban, Emma Tintea, Daniela Bartos, Nicoleta Alexandru, Adriana Georgescu. Midkine in cardio-vascular disease: Where do we come from and where are we heading to? European Journal of Pharmacology, 762:464-471, 2015. - impact factor 2.68
36. Josune Orbe, Nicoleta Alexandru, Carmen Roncal, Miriam Belzunce, Paula Bibiot, Jose A Rodriguez, Joost C Meijers, Adriana Georgescu, Jose A Paramo. Lack of TAFI increases brain damage and microparticle generation after thrombolytic therapy in ischemic stroke. Thrombosis Research, 136: 445-450, 2015. - impact factor 2.42
37. Nicoleta Alexandru, Elisabeta Badila, Ana Costa, Daniel Cochior, Adriana Georgescu.
Microparticles: from biogenesis to biomarkers and diagnostic tools in cardiovascular disease - accepted to - Current Stem Cell Research and Therapy , 2015- impact factor 2.86

Articles published in journals indexed for the international database
1. A. Georgescu, D. Popov, M. Hasu. Quantitative fluorimetric analysis of advanced glycosylation end products in mesenteric arteries and lens crystallin of hyperlipemic and simultaneously hyperlipemic and hyperglycemic hamsters. Current Problems and Techniques in Cellular and Molecular Biology edited by A. Ardelean et. Al., vol. 2, 65-68, 1997.
2. G. Costache, M. Hasu, D. Popov, A. Georgescu. The use of the myograph technique for the investigation of the vascular reactivity: A review. Current Problems and Techniques in Cellular and Molecular Biology edited by A. Ardelean et. Al., vol. 2, 38-43, 1997,
3. A. Georgescu, D. Popov, G. Costache. Vascular reactivity of resistance arteries of hyperlipemic-hyperglycemic hamsters in the presence of vasoconstrictor agents. Current Problems and Techniques in Cellular and Molecular Biology edited by A. Ardelean et. al., vol. 3, 124-129, 1998.
4. A. Georgescu, D. Popov. Influence of experimental diabetes on the cells of vascular wall. Studii si Cercetari de Biochimie, vol. 41, 107-117, 1998.
5. G. Costahe, D.Popov, A. Georgescu, M. Simionescu. Functional-structural alterations of the resistance arteries in experimental hyperlipemia or hypergliycemia. Proceedings of the Romanian Academy. Series.B. vol.1, 33-37, 1999
6. A. Georgescu, D. Popov. Vascular reactivity of the resistance arteries to potassium in combined hyperlipemia-hyperglycemia. Proceedings of the Romanian Academy nr.3, 111-117, 2001.
7. A. Georgescu, D. Popov, L. Vladimirescu. Effect of blocking the intercellular communication junctions on the contractile response of the resistance arteries. Current Problems in Cellular and Molecular Biology edited by A. Ardelean et. al., vol VI, 85-90, 2001.
8. L. Radu, C. Stavaru, A. Georgescu, D. Popov, C. Coman. Transgenic mouse model of type 1 Diabetes. Proceedings of the Japanese Society for Immunology, 32, 11, 2002.
9. D. Popov, A. Georgescu, G. Ccostache. Perturbarea reactivitatii arterelor de rezistenta, manifestare a disfunctiei vasculare in diabet. Romanian Heart Journal, 20 (3), 216-223, 2005.
10. Adriana Georgescu, Florentina Safciuc, Elena Constantinescu. The effect of aging on the vasomotor function of rat basilar artery. Proc. Rom. Acad., Series B, 1, 13-17, 2006.
11. Miruna Nemecz, Doina Popov, Adriana Georgescu. Phosphorylation/dephosphorylation signaling events in the aorta of streptozotocin-injected Golden Syrian Hamsters. Annals of RSCB, vol XV, issue 1, 28-34, 2010.
12. C.S. Stancu, A. Georgescu, L. Toma,G.M. Sanda, A.V. Sima. Glycated low density lipoproteins alter vascular reactivity in hyperlipidemic hyperglycemic hamsters; Annals of RSCB. 17(1), 9-15, 2012.
13. Nicoleta Alexandru, Elisabeta Badila, Adriana Georgescu. The role of endothelial progenitor cells in the cardiovascular disease pathogenesis. J Stem Cells Res, Rev & Rep.1(2): 1-2, 2014.
14. Nicoleta Alexandru, Adriana Georgescu. Microparticles as players in the pathogenesis of cardiovascular disease. Fisiología, 2015, vol. 18(1):9-14. ISSN:1889-397X.


Books
1. Adriana Georgescu, Felicia Antohe. Editor of the international monograph 'From Vascular Cell Biology to Cardiovascular Medicine' published by RESEARCH SIGNPOST TRANSWORLD RESEARCH NETWORK, Trivandrum - 695023, Kerala, India, ISBN - 978-81-7895-503-2, 2011.
2. Adriana Georgescu. Cardiovascular Dysfunction: New Biomarkers and Therapies. Published by Scholars' Press, OmniScriptum GmbH & Co. KG, Saarbrücken, Germany, ISBN -978-3-639-71643-6, 2014.

Chapters in books
1. Doina Popov, Gabriela Costache, Adriana Georgescu. Altered vascular reactivity of the resistance arteries: lessons from the hyperlipemic-hyperglycemic hamster model, ‘New insights into experimental diabetes’, Ed: D.M.Cheta, The Publishing House of The Romanian Academy, ISBN: 973-27-0871-9, 211-222, 2001.
2. Adriana Georgescu, Nicoleta Alexandru, Doina Popov. Ongoing data on vascular endothelial cell dysfunction: an update. ‘From Vascular Cell Biology to Cardiovascular Medicine’, Ed: Adriana Georgescu, Felicia Antohe, published by RESEARCH SIGNPOST TRANSWORLD RESEARCH NETWORK, ISBN - 978-81-7895-503-2, 125 – 141. 2011.

Selected publications:
• Josune Orbe, Nicoleta Alexandru, Carmen Roncal, Miriam Belzunce, Paula Bibiot, Jose A Rodriguez, Joost C Meijers, Adriana Georgescu, Jose A Paramo. . Lack of TAFI increases brain damage and microparticle generation after thrombolytic therapy in ischemic stroke. . Thrombosis Research, 136, p. 445–450, 2015.
• Elisabeta Badila, Ana Maria Daraban, Emma Tintea, Daniela Bartos, Nicoleta Alexandru, Adriana Georgescu. . Midkine in cardio-vascular disease: Where do we come from and where are we heading to? . European Journal of Pharmacology, 762, pp. 464-471, 2015.
• Nicoleta Alexandru, Eugen Andrei, Emanuel Dragan, Adriana Georgescu. Interaction of platelets with endothelial progenitor cells in the experimental atherosclerosis; the role of transplanted endothelial progenitor cells and platelet microparticles. Biology of The Cell, 107, p. 189–204, 2015.
• Eugen Andrei, Nicoleta Alexandru, Emanuel Dragan, Adriana Georgescu. . Flow cytometric analysis of circulating microparticles and endothelial progenitor cells in plasma; a research tool for atherosclerosis and therapy. . Experimental and Clinical Cardiology, 20 (7), pp. 1554-1563, 2014.
• Elisabeta Badila, Ana Maria Daraban, Silviu Ghiorghe, Adriana Georgescu, Nicoleta Alexandru, Daniela Bartos, Cristina Tirziu. Rethinking cardiovascular therapy - the effect of irbesartan on circulating microparticles and endothelial progenitor cells in patients with hypertension and dyslipidemia. . Farmacia, 93-106, pp. 93-106, 2014.
• Nicoleta Alexandru, Adriana Georgescu. Circulating microparticles and microRNAs as players in atherosclerosis. World Journal of Hematology, 2(2), pp. 16-19, 2013.
• Bich-Hoai Thi Ton, Qingmin Chen, Gisela Gaina, Catalin Tucureanu, Adriana Georgescu, Carmen Strungaru, Maria-Luiza Flonta, Dinah Sah, Violeta Ristoiu. Activation profile of dorsal root ganglia Iba-1 (+) macrophages varies with the type of lesion in rats. Acta Histochemica, 115(8), pp. 840-850, 2013.
• Adriana Georgescu, Nicoleta Alexandru, Miruna Nemecz, Irina Titorencu, Doina Popov. Irbesartan administration therapeutically influences circulating endothelial progenitor cell and microparticle mobilization by involvement of pro-inflammatory cytokines. European Journal of Pharmacology, 711, pp. 27-35, 2013.
• Nicoleta Alexandru, Doina Popov, Emanuel Dragan, Eugen Andrei, Adriana Georgescu. Circulating endothelial progenitor cell and platelet microparticle impact on platelet activation in hypertension associated with hypercholesterolemia. PloS One, 8(1), pp. e52058-e52, 2013.
• Adriana Georgescu, Nicoleta Alexandru, Eugen Andrei, Irina Titorencu, Emanuel Dragan, Cristina Tarziu, Silviu Ghiorghe, Elisabeta Badila, Daniela Bartos, Doina Popov. Ratio of circulating microparticles to endothelial progenitor cells as a new marker of vascular atherosclerosis; effect of irbesartan . Journal of Thrombosis and Haemostasis , 2012.
• Nicoleta Alexandru, Doina Popov, Adriana Georgescu. Platelet dysfunction in vascular pathologies and how can it be treated. Thrombosis Research, 129, pp. 116-126, 2012.
• I Titorencu, M. G. Albu, F. Anton, A. Georgescu, V. V. Jinga. Collagen - dexamethasone and collagen-D3 scaffolds for bone tissue engineering. Molecular Crystals and Liquid Crystals, 555, pp. 1-10, 2012.
• Adriana Georgescu, Nicoleta Alexandru, Andrei Constantinescu, Irina Titorencu, Doina Popov. The promise of EPCs-based therapies on vascular dysfunction in diabetes. European Journal of Pharmacology, doi:10.1016/j.ejphar.2011.07.035, 2011.
• Adriana Georgescu. Vascular dysfunction in diabetes: the endothelial progenitor cells as new therapeutic strategy. . World Journal of Diabetes, 2(6), pp. 92-97, 2011.
• Marilena Lupu, Markus Khalil, Eugen Andrei, Florin Iordache, Kurt Pfannkuche, Klaus Neef, Adriana Georgescu, Cosmin Buzila, Konrad Brockmeier, Horia Maniu, Jürgen Hescheler. Integration properties of Wharton’s jelly-derived novel mesenchymal stem cells into ventricular slices of murine hearts. Cellular Physiology and Biochemistry, 28, pp. 63-76, 2011.
• Nicoleta Alexandru, Adriana Georgescu, Manuela Amuzescu, Constantin Zamfir, Adrian Badila, Doina Popov. Platelet reactivity in chronic venous insufficiency. Clinical Laboratory, 57(7-8), pp. 527-534, 2011.
• Adriana Georgescu, Nicoleta Alexandru, Miruna Nemecz, Irina Titorencu, Doina Popov . Enoxaparin reduces adrenergic contraction of resistance arterioles in aging and in aging associated with diabetes via engagement of MAP kinase pathway. Blood Coagulation and Fibrinolysis, 22(4), pp. 310-316, 2011.
• Adriana Georgescu, Felicia Antohe. Editor. From Vascular Cell Biology to Cardiovascular Medicine. RESEARCH SIGNPOST TRANSWORLD RESEARCH NETWORK, Trivandrum - 695023, Kerala, India, 2011.
• Nicoleta Alexandru, Doina Popov, Emanuel Dragan, Eugen Andrei, Adriana Georgescu. Platelet activation in hypertension associated with hypercholesterolemia; effects of irbersartan. Journal of Thrombosis and Haemostasis, 9, pp. 173-184, 2011.
• Adriana Georgescu, Doina Popov, Anamaria Constantin, Miruna Nemecz, Nicoleta Alexandru, Daniel Cochior, Aura Tudor. Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with Type 2 diabetes. Clinical Science, 120, pp. 463-472, 2011.
• N. Alexandru, D. Popov, A. Georgescu. Intraplatelet oxidative/nitrative stress: inductors, consequences, and contro. Trends Cardiovasc Med, 20 , p. 232–, 2010.
• Sadri Chahed, Aurélie S. Leroyer, Mounir Benzerroug, David Gaucher, Adriana Georgescu, Serge Picaud, Jean-Sébastien Silvestre, Alain Gaudric, Alain Tedgui, Pascale Massin, Chantal M. Boulange. . Increased vitreous shedding of microparticles in proliferative diabetic retinopathy stimulates endothelial proliferation. . Diabetes, 59, pp. 694-701, 2010.
• Popov Doina, Nemecz Miruna, Dumitrescu Madalina, Georgescu Adriana, Böhmer Frank D. . Long-term high glucose concentration influences Akt, ERK1/2, and PTP1B protein expression in human aortic smooth muscle cells. . Biochemical and Biophysical Research Communications, 388, pp. 51-55, 2009.
• Adriana Georgescu, Nicoleta Alexandru, Doina Popov, Manuela Amuzescu, Eugen Andrei, Constantin Zamfir, Horia Maniu, Adrian Badila . . Chronic venous insufficiency is associated with elevated level of circulating microparticles. . Journal of Thrombosis and Haemostasis, 7, pp. 1566-1575, 2009.
• A. Georgescu, F. Pluteanu, M-L. Flonta, E. Badila, M. Dorobantu, D. Popov. Nebivolol induces the hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of the b2 - adrenoceptor. . Pharmacology, 81, pp. 110-117, 2008.
• Adriana Georgescu, Doina Popov, Emanuel Dragan, Elena Dragomir, Elisabeta Badila. . Protective effects of nebivolol and reversal of endothelial dysfunction in diabetes associated with hypertension. . European Journal of Pharmacology, 570, pp. 149-158, 2007.

Publications from the ISI database, indexed between 2002-2011, produced in Romania:
• Popov, D; Costache, G; Georgescu, A; Enache, M, Beneficial effects of L-arginine supplementation in experimental hyperlipemia-hyperglycemia in the hamster. CELL AND TISSUE RESEARCH, 308 (1), pp. 109-120, 2002.
• Georgescu, A; Popov, D; Simionescu, M, Mechanisms of decreased bradykinin-induced vasodilation in experimental hyperlipemia-hyperglycemia: contribution of nitric oxide and Ca2+-activated K+ channels. FUNDAMENTAL & CLINICAL PHARMACOLOGY, 15 (5), pp. 335-342, 2001.
• Georgescu, A; Popov, D, The contractile response of the mesenteric resistance arteries to prostaglandin F-2 alpha; effects of simultaneous hyperlipemia-diabetes. FUNDAMENTAL & CLINICAL PHARMACOLOGY, 17 (6), pp. 683-689, 2003.
• Badila, E; Georgescu, A; Popov, D; Dorobantu, M; Simionescu, M, The effect of nebivolol on the altered vascular reactivity of the renal artery in diabetic mouse. JOURNAL OF HYPERTENSION, 21, p. S201, 2003.
• Georgescu, A; Popov, D; Capraru, M; Simionescu, M, Enoxaparin - low molecular weight heparin, restores the altered vascular reactivity of resistance arteries in aged and aged-diabetic hamsters. VASCULAR PHARMACOLOGY, 40 (3), pp. 167-174, 2003.
• Voinea, M; Georgescu, A; Manea, A; Dragomir, E; Manduteanu, I; Popov, D; Simionescu, M, Superoxide dismutase entrapped-liposomes restore the impaired endothelium-dependent relaxation of resistance arteries in experimental diabetes. EUROPEAN JOURNAL OF PHARMACOLOGY, 484 (1), pp. 111-118, 2004.
• Badila, E; Tirziu, C; Stefuriac, M; Georgescu, A; Bartos, D; Dorobantu, M, The role of electric thoracic bioimpedance in the control of arterial hypertension. JOURNAL OF HYPERTENSION, 23, p. S152, 2005.
• Georgescu, A, The cellular mechanisms involved in the vasodilator effect of nebivolol on the renal artery. JOURNAL OF HYPERTENSION, 23, p. S239, 2005.
• Georgescu, A; Pluteanu, F; Flonta, ML; Badila, E; Dorobantu, M; Popov, D, The cellular mechanisms involved in the vasodilator effect of nebivolol on the renal artery. EUROPEAN JOURNAL OF PHARMACOLOGY, 508 (1-3), pp. 159-166, 2005.
• Georgescu, A; Alexandru, N; Constantinescu, E; Popov, D, Effect of gap junction uncoupler heptanol on resistance arteries reactivity in experimental models of diabetes, hyperlipemia and hyperlipemia-diabetes. VASCULAR PHARMACOLOGY, 44 (6), pp. 513-518, 2006.
• Schneider, M; Georgescu, A; Bidmon, C; Tutsch, M; Fleischmann, EH; Popov, D; Pischetsrieder, M, Detection of DNA-bound advanced glycation end-products by immunoaffinity chromatography coupled to HPLC-diode array detection. MOLECULAR NUTRITION & FOOD RESEARCH, 50 (4-5), pp. 424-429, 2006.
• Georgescu, A; Popova, D; Dragan, E; Dragomir, E; Badila, E, Protective effects of nebivolol and reversal of endothelial dysfunction in diabetes associated with hypertension. EUROPEAN JOURNAL OF PHARMACOLOGY, 570 (1-3), pp. 149-158, 2007.
• Georgescu, A; Popov, D; Alexandru, N; Tudor, A; Simionescu, M, Structural and functional assessment of small arteries in obesity and type 2 diabetes. ATHEROSCLEROSIS SUPPLEMENTS, 8 (1), p. 229, 2007.
• Voinea, M; Georgescu, A; Manea, A; Dragomir, E; Manduteanu, I; Popov, D; Simionescu, M, Superoxide dismutase entrapped-liposomes restore the impaired endothelium-dependent relaxation of resistance arteries in experimental diabetes. JOURNAL OF VASCULAR RESEARCH, 43, p. 18, 2006.
• Georgescu, A; Popov, D; Dragomir, E; Dragan, E; Simionescu, M, Nebivolol protects and reverses endothelial dysfunction in diabetes associated with hypertension; Molecular mechanisms involved. JOURNAL OF VASCULAR RESEARCH, 43, p. 81, 2006.
• Georgescu, A; Popov, D; Dragomir, E; Neagoe, C; Simionescu, M, Protective role of nebivolol on the renal artery dysfunction in diabetes associated with hypertension; Molecular mechanisms involved. JOURNAL OF HYPERTENSION, 24, p. S389, 2006.
• Georgescu, A; Pluteanu, F; Flonta, ML; Badila, E; Dorobantu, M; Popov, D, Nebivolol induces a hyperpolarizing effect on smooth muscle cells in the mouse renal artery by activation of beta-2-adrenoceptors. PHARMACOLOGY, 81 (2), pp. 110-117, 2008.
• Georgescu, A; Alexandru, N; Popov, D; Amuzescu, M; Andrei, E; Zamfir, C; Maniu, H; Badila, A, Chronic venous insufficiency is associated with elevated level of circulating microparticles. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 7 (9), pp. 1566-1575, 2009.
• Popov, LD; Nemecz, M; Dumitrescu, M; Georgescu, A; Bohmer, FD, Long time culture of human aortic smooth muscle cells in high glucose concentration up-regulates ERK1/2 activation and PTP1B protein expression. DIABETOLOGIA, 52, pp. 1336-, 2009.
• Popov, D; Nemecz, M; Dumitrescu, M; Georgescu, A; Bohmer, FD, Long-term high glucose concentration influences Akt, ERK1/2, and PTP1B protein expression in human aortic smooth muscle cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 388 (1), pp. 51-55, 2009.
• Chahed, S; Leroyer, AS; Benzerroug, M; Gaucher, D; Georgescu, A; Picaud, S; Silvestre, JS; Gaudric, A; Tedgui, A; Massin, P; Boulanger, CM, Increased Vitreous Shedding of Microparticles in Proliferative Diabetic Retinopathy Stimulates Endothelial Proliferation. DIABETES, 59 (3), pp. 694-701, 2010.
• Georgescu, A; Alexandru, N; Popov, D; Andrei, E; Titorencu, I; Dragan, E; Tarziu, C; Ghiorghe, S; Badila, E; Bartos, D; Simionescu, M, RATIO OF MICROPARTICLES TO ENDOTHELIAL PROGENITOR CELLS, A MARKER OF VASCULAR DYSFUNCTION INDUCED BY COMBINED HYPERTENSION AND HYPERCHOLESTEROLEMIA; IRBERSARTAN EFFECT. ATHEROSCLEROSIS SUPPLEMENTS, 11 (2), pp. W55-, 2010.
• Alexandru, N; Georgescu, A; Popov, D; Andrei, E; Dragan, E; Simionescu, M, IRBESARTAN REDUCES PLATELET ACTIVATION IN HYPERTENSIVE-HYPERCHOLESTEROLEMIC HAMSTER. ATHEROSCLEROSIS SUPPLEMENTS, 11 (2), pp. MS357-, 2010.
• Alexandru, N; Popov, D; Dragan, E; Andrei, E; Georgescu, A, Platelet activation in hypertension associated with hypercholesterolemia: effects of irbesartan. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 9 (1), pp. 173-184, 2011.
• Tirziu, C; Georgescu, A; Badila, E; Ghiorghe, S; Tirziu, R; Bartos, D, CAN WE USE THE RATIO BETWEEN CIRCULATING MICROPARTICLES AND ENDOTHELIAL PROGENITOR CELLS LIKE A MARKER OF THE ENDOTHELIAL DYSFUNCTION IN HYPERTENSIVE-HYPERCHOLESTEROLEMIC PATIENTS?. JOURNAL OF HYPERTENSION, 28, p. E124, 2010.
• Georgescu, A; Alexandru, N; Nemecz, M; Titorencu, I; Popov, D, Enoxaparin reduces adrenergic contraction of resistance arterioles in aging and in aging associated with diabetes via engagement of MAP kinase pathway. BLOOD COAGULATION & FIBRINOLYSIS, 22 (4), pp. 310-316, 2011.
• Georgescu, A; Popov, D; Constantin, A; Nemecz, M; Alexandru, N; Cochior, D; Tudor, A, Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with Type 2 diabetes. CLINICAL SCIENCE, 120 (9-10), pp. 463-472, 2011.
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