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Florina Raicu

Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

Institution web page: http://www.univermed-cdgm.ro
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Born: 1975

Interests: molecular genetics, Y chromosome, haplogroups, microdeletions, male infertility, microarray technology, biopaleoanthropology, biostatistics

Details:
My specific research interest is the study of the human transcriptome based on the characterization global gene expression profiling of normal and pathological male germ cells by microarray analysis and the effect of the Y chromosome genes on brain development. I investigated some Y chromosome haplogrups associated with spermatogenic failure in the Romanian population and the genetic background of male infertility based on the Y chromosome microdeletion analysis. I am also interested in investigations of the androgen receptor (AR) gene mutations associated with Androgen Insensitivity Syndrome, molecular genetics investigations regarding PAX9 gene mutations, molecular genetics ivestigations in ATP7B gene mutations associated with Wilson disease and new analysis methods of the ancient DNA.

EDUCATION:
1994 - 1998
Faculty of Biology, University of Bucharest, Specialization in Genetics
Bachelor of science in Molecular Biology
1998 - 2000
Faculty of Biology, University of Bucharest, Master in Genetics
2004 - 2007
Ph.D. school "Functional Neuroimaging: from cells to systems"
Institute of Advanced Biomedical Technologies, co-funded by the European Union in the FP3
Department of Clinical Sciences and Bioimaging
G. d'Annunzio Chieti University - Pescara ITALY
PhD in Medical Genetics
2001 - 2008
Francisc I.Rainer Anthropological Research Institute, Romanian Academy, Bucharest
Medical Anthropology Department.
PhD in Medical Science.

EMPLOYMENT:
1998 - 2000
Francisc I.Rainer Anthropological Research Institute, Romanian Academy, Bucharest - Research scientist (full time)
2000 - 2004
Institute of Genetics, University of Bucharest - research scientist (full time)
2000 - present
Francisc I.Rainer Anthropological Research Institute, Romanian Academy, Bucharest - Research scientist (part time)
2007 - present
Carol Davila University of Medicine and Pharmacy, Bucharest, Faculty of Medicine,Genetics Chair - Assistant professor

REVIEWER:
1. HUMAN MOLECULAR GENETICS - Oxford University Press Online ISSN 1460-2083 (impact factor 8.099)
2. JOURNAL OF ANDROLOGY - Allen Press, ISSN0196-3635, American Society of Andrology (impact factor 2.035 )

Selected publications:
• Gatta V, Raicu F, Ferlin A, Antonucci I, Scioletti AP, Garolla A, Palka G, Foresta C, Stuppia L. Testis transcriptome analysis in male infertility: new insight on the pathogenesis of oligo-azoospermia in cases with and without AZFc microdeletion. . BMC Genomics, Jun 24;11:401, 2010.
• F. Raicu, R. Cocos, A. Sendroiu, D. Neagos, R. Cretu, C. Glavce, L. Bohiltea, I. Sendroiu. High prevalence of Wilson disease in a small mountain village in Romania. In EUROPEAN HUMAN GENETICS CONFERENCE, Barcelona SPAIN. 2008.
• V. Gatta, F. Raicu, A. Scioletti, A. Ferlin, G. Palka, C. Foresta, L. Stuppia. Gene expression profiling of normal and pathological testis by microarray analysis. In EUROPEAN HUMAN GENETICS CONFERENCE, Barcelona SPAIN. 2008.
• Tete S, Mastrangelo F, Scioletti AP, Tranasi M, Raicu F, Paolantonio M, Stuppia L, Vinci R, Gherlone E, Ciampoli C, Sberna MT, Conti P. . Microarray expression profiling of human dental pulp from single subject. Clin. Invest. Med, 31(2), pp. E:55-61, 2008.
• Florina Raicu, R. Giuliani, V. Gatta, C. Palka, P. Guanciali Franchi, P. Lelli-Chiesa, S. Tumini, L. Stuppia. A Novel Mutation in the Ligand-Binding Domain of the Androgen Receptor gene (L790P) associated with Complete Androgen Insensitivity Syndrome. Asian Journal of Andrology, Jul;10(4), pp. 687-691, 2008.
• Varzari A, Kharkov V, Stephan W, Raicu F, Dergachev V, Puzyrev VP, Stepanov V, Weiss E. Alu polymorphisms and Y-chromosome variation in the Dniester-Carpathian region. In THE 9TH INTERNATIONAL MEETING ON HUMAN GENOME VARIATION AND COMPLEX GENOME ANALYSIS, Barcelona, SPAIN. 2007.
• R. Cocos, F. Raicu, D. Neagos. Identification of reduced copy number of DAZ genes in a group of Romanian idiopathic infertile men. In EUROPEAN HUMAN GENETICS CONFERENCE, Nice Acropolis Center FRANCE. 2007.
• S. Schipor, R. Cocos, E. Paune-Buse, I. Nicolae, R. Cretu, A. Stefanescu-Winterlike, F. Raicu. The relationship between the -765G>C COX-2 polymorphism and the development of cutaneous inflammatory process. In EUROPEAN HUMAN GENETICS CONFERENCE, Nice Acropolis Center FRANCE. 2007.
• Raicu F, V. Gatta, A. Ferlin, C. Foresta, G. Palka, L. Stuppia. Expression profiling of human normal testis by microarray technology. In EUROPEAN HUMAN GENETICS CONFERENCE, Nice Acropolis Center FRANCE. 2007.
• A Ferlin, F Raicu, V Gatta, D Zuccarello, G Palka, C Foresta. Male infertility: role of genetic background. Reproductive BioMedicine Online, Vol 14. No 6, pp. 734-745, 2007.
• Varzari A, Stephan W, Stepanov V, Raicu F, Cojocaru R, Roschin Y, Glavce C, Dergachev V, Spiridonova M, Schmidt HD, Weiss E. . Population history of the Dniester-Carpathians: evidence from Alu markers. Journal of Human Genetics, 52(4):, pp. 308-16, 2007.
• L. Popa, F. di Giacomo, O. Popa, F. Raicu, N. Coman. Remarkable homogeneity of the human Y chromosome P lineage at the level of alphoid heteroduplex polymorphic system. In EUROPEAN HUMAN GENETICS CONFERENCES 2006 AMSTERDAM, THE NETHERLANDS. 2006.
• O. Scarciolla, L. Stuppia, M. V. De Angelis, S. Murru, F. Raicu, R. Giuliani, M. Pace, I. Antonucci, A. P. Scioletti, I. Torrente, P. Grammatico, M. C. Rosatelli, A. Uncini, G. Palka, B. Dallapiccola. Spinal muscular Atrophy (smA) genotyping by gene dosage using Multiple Ligation-dependent Probe Amplification (mLPA). In EUROPEAN HUMAN GENETICS CONFERENCES 2006 AMSTERDAM, THE NETHERLANDS. 2006.
• Vinci G, Raicu F, Popa L, Popa O, Cocos R, McElreavey K., . A deletion of a novel heat shock gene on the Y chromosome associated with azoospermia. Molecular Human Reproduction, Apr;11(4), pp. 295-8, 2005.
• Popa LO, Di Giacomo F, Popa OM, Raicu F, Coman N. . Multiplex PCR for the assignment of some major branches of the Y chromosome tree. Journal of Genetics, dec;84(3), pp. 303-6, 2005.
• F. Raicu, L. O. Popa, O. M. Popa, L. Ilinca, L. L. Dracea, B. Marinescu, L. Gavrila. A Romanian population study of 10 Y-chromosome STS loci from infertile men. In EUROPEAN HUMAN GENETICS CONFERENCE 2004, INTERNATIONAL CONGRESS CENTER, MUNICH, GERMANY. 2004.
• Schmidt H. D., Glavce C., Raicu F., Apavaloae L., Grasa, C. Frequencies of some Genetic Markers in an Aromun Population in Dobruja. In EUROPEAN ANTHROPOLOGICAL ASSOCIATION 14TH INTERNATIONAL CONGRESS HUMAN VARIABILITY: A BRIDGE BETWEEN SCIENCES AND HUMANITIES, Komotini, GREECE. 2004.
• Florina Raicu , L. Popa , Pompilia Apostol , D. Cimponeriu , Letitia Dan , Elena Ilinca , Laura Luana Dracea , B. Marinescu , L. Gavrila. Screening for microdeletions in human Y chromosome -AZF candidate genes and male infertility. Journal of Cellular and Molecular Medicine, vol.7, nr.1, pp. 43-48, 2003.
• Luis Popa, Ionela Moanta, Florina Raicu, Dan Cimponeriu, Apostol Pompilia, Gabi Bordeianu and Lucian Gavrila. Alphoid heteroduplex polymorphism in sample populations of Romania. In HUMAN GENOME MEETING, SHANGHAI, CHINA. 2002.

Publications from the ISI database, indexed between 2002-2011, produced in Romania:
• Raicu, F; Popa, L; Apostol, P; Cimponeriu, D; Dan, L; Ilinca, E; Dracea, LL; Marinescu, B; Gavrila, L, Screening for microdeletions in human Y chromosome - AZF candidate genes and male infertility. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 7 (1), pp. 43-48, 2003.
• Vinci, G; Raicu, F; Popa, L; Popa, O; Cocos, R; McElreavey, K, A deletion of a novel heat shock gene on the Y chromosome associated with azoospermia. MOLECULAR HUMAN REPRODUCTION, 11 (4), pp. 295-298, 2005.
• Popa, LO; Di Giacomo, F; Popa, OM; Raicu, F; Coman, N, Multiplex PCR Tor the assignment of some major branches of the Y chromosome tree. JOURNAL OF GENETICS, 84 (3), pp. 303-306, 2005.
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