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Gertrude-Emilia Costin

Institute for In Vitro Sciences, Gaithersburg, USA

Institution web page: http://www.iivs.org
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Born: 1974

Interests: pigmentation

Details:
background in glycobiology, cell and molecular biology, pigmentation, cosmetic industry, toxicology

Selected publications:
• Birlea, S. A.; Costin, G. -E.; Norris, D. A. . Cellular and Molecular Mechanisms Involved in the Action of Vitamin D Analogs Targeting Vitiligo Depigmentation. Current Drug Targets, 9 (4), pp. 345-359, 2008.
• Costin, GE, Hearing, VJ. . Human skin pigmentation: melanocytes modulate skin color in response to stress. . FASEB J, 21(4), pp. 976-994, 2007.
• Valencia, J. C., Rouzaud, F., Julien, S., Chen, K. G., Passeron, T., Yamaguchi, Y., Abu-Asab, M., Tsokos, M., Costin, G. E., Yamaguchi, H., Miller Jenkins, L. M., Nagashima, K., Appella, E., Hearing, V. J. . Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils. . J. Biol. Chem. , 258(5), pp. 11266-1128, 2007.
• Gertrude-E. Costin, Stanca A. Birlea. What is the mechanism for the pigmentation that so commonly accompanies human pregnancy?. IUBMB Life, 58 (1), pp. 55-57, 2006.
• Stanca Birlea, Marius Birlea, Danut Cimponeriu, Pompilia Apostol, Rodica Cosgarea, Lucian Gavrila, Stefan Tigan, Gertrude Costin, Pranab K. Das. Autoimmune diseases and vitamin D receptor Apa-I polymorphism are associated with vitiligo in a small inbred Romanian community. Acta Derm. Venereol. , 86 (3), pp. 209-214, 2006.
• F. Rouzaud, G-E. Costin, Y. Yamaguchi, J. C. Valencia, W. F. Berens, K. G. Chen, T. Hoashi, M. Bohm, Z. A. Abdel-Malek, V. J. Hearing. Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms. FASEB J, 20 (11), pp. 1927-1929, 2006.
• Greggio, E., Bergantino, E., Carter, D., Ahmad, R., Costin G. -E., Hearing, V. J., Clarimon, J., Singleton, A., Eerola, J., Hellstr÷m, O., Tienari, P. J., Miller, D. W., Beilina, A., Bubacco, L., Cookson, M. R. . Tyrosinase exacerbates dopamine and & #61537; -synuclein toxicity but is not genetically associated with Parkinson' s disease. J. Neurochem. , 93, pp. 246-256, 2005.
• Gertrude-E. Costin, Julio C. Valencia, Kazumasa Wakamatsu, Shosuke Ito, Wilfred D. Vieira, Yuji Yamaguchi, Adina L. Milac, Franšois Rouzaud, Andrei-J. Petrescu, M. Lynn Lamoreux, Vincent J. Hearing. Mutations in the mouse Dct gene induce a reduction of eumelanin and an increase in the level of pheomelanin produced by melanocytes in culture. Biochem. J. , 391 (2), pp. 249-259, 2005.
• Hideya Ando, Zhi-Ming Wen, Hee-Yong Kim, Norman Salem, Jr., Julio C. Valencia, Gertrude-E. Costin, Hidenori Watabe, Ken-ichi Yasumoto, Yoko Niki, Hirofumi Kondoh, Masamitsu Ichihashi, Vincent J. Hearing. Modulating the intracellular composition of fatty acids affects the post-Golgi degradation of tyrosinase and elicits its retention in the endoplasmic reticulum by hyper-ubiquitination and proteasome inhibition. Biochem. J. , 394 (1), pp. 43-50, 2005.
• Costin, G. -E. . What is the advantage of having melanin in parts of the central nervous system (e. g. substantia nigra)?. IUBMB Life, 56 (1), pp. 47-49, 2004.
• Costin, G. -E., Vieira, W. D., Valencia, J. C., Rouzaud, F., Lamoreux, M. L., Hearing, V. J. . Immortalization of mouse melanocytes carrying mutations in various pigmentation genes. Anal. Biochem. , 335 (1), pp. 170-174, 2004.
• Kushimoto, T., Valencia, J. C., Costin, G. -E., Toyofuku, K., Watabe, H., Yasumoto, K. -I., Rouzaud, F., Vieira, W. D., Hearing, V. J. . " Makoto Seiji memorial lecture" : The melanosome: an ideal model to study cellular differentiation" (review). Pigment Cell Res. (Proceedings of the XVIIIth International Pigment Cell Conference (IPCC)), 16 (3), pp. 237-244, 2003.
• Costin, G. -E., Valencia, J. C., Vieira, W. D., Lamoreux, M. L., Hearing, V. J. . Tyrosinase processing and intracellular trafficking is disrupted in mouse primary melanocytes carrying the underwhite (uw) mutation. A model for oculocutaneous albinism (OCA) Type 4. J. Cell. Sci. , 116 (15), pp. 3203-3212, 2003.
• Rouzaud, F., Annereau, J. -P., Valencia, J. C., Costin, G. -E., Hearing, V. J. . Regulation of melanocortin 1 receptor expression at the mRNA and protein levels by its natural agonist and antagonist. FASEB J. , 17 (14), pp. 2154-2156, 2003.
• Toyofuku, K., Valencia, J. C., Kushimoto, T., Costin, G. -E., Virador, V. M., Vieira, W. D., Ferrans, V. J., Hearing, V. J. . The etiology of oculocutaneous albinism (OCA) type II: the pink protein modulates the processing and transport of tyrosinase. Pigment Cell Res. , 15 (3), 217-224, pp. 217-224, 2002.
• Costin, G. -E., Trif, M., Nichita, N., Dwek, R. A., Petrescu, S. M. . pH-sensitive liposomes are efficient carriers for endoplasmic reticulum targeted drugs in mouse melanoma cells. BBRC, 293 (3), pp. 918-923, 2002.
• Costin, G. -E., Petrescu S. M. . Inhibitors of N-linked glycoproteins biosynthesis and processing. Rom. J. Biochem. , 38 (2), pp. 233-249, 2001.
• Negroiu, G., Branza-Nichita, N., Costin, G. -E., Titu, H., Petrescu, A. -J., Dwek, R. A., Petrescu, S. M. . Investigation of the intracellular transport of tyrosinase and tyrosinase related protein (TRP-1). The effect of endoplasmic reticulum (ER)-glucosidases inhibition. Cell. Mol. Biol (Melanocytes and Melanogenesis), 45 (7), pp. 1001-1010, 1999.
• Costin, G. -E., Fatu, C., . Molecular mechanisms and therapeutics concerning acquired immunodeficiency syndrome. Stud. And Res. Of Biochim., , 41 (1-2), pp. 73-87, 1998.
• Costin, G. -E., Fatu, C., Bostangiu, M. . Tumoral markers in cancer. Stud. And Res. Of Biochim. , 41 (1-2), pp. 89-96, 1998.


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