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Alexandru Babes

Universitatea Bucuresti, Bucuresti, Romania

Institution web page: http://biologie.kappa.ro
Personal web page: http://biologie.kappa.ro
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Born: 1971

Interests: pain, neuroscience, ion channels, cold, inflammation

Details:
My research is focused on the peripheral mecahnisms of nociception and thermal transduction. We are studying the activation and modulation of a variety of ion channels and receptors expressed in peripheral nerve endings, such as TRPV1, TRPV2,TRPM8 and TRPA1.

ResearcherID: A-6212-2010

Selected publications:
• Bierhaus A, Fleming T, Stoyanov S, Leffler A, Babes A, Neacsu C, Sauer SK, Eberhardt M, Schnölzer M, Lasischka F, Neuhuber WL, Kichko TI, Konrade I, Elvert R, Mier W, Pirags V, Lukic IK, Morcos M, Dehmer T, Rabbani N, Thornalley PJ, Edelstein D, Nau C, Fo. Methylglyoxal modification of Na(v)1. 8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nature Medicine, 2012.
• Engel, MA; Leffler, A; Niedermirtl, F; Babes, A; Zimmermann, K; Filipovic, MR; Izydorczyk, I; Eberhardt, M; Kichko, TI; Mueller-Tribbensee, SM; Khalil, M; Siklosi, N; Nau, C; Ivanovic-Burmazovic, I; Neuhuber, WL; Becker, C; Neurath, MF; Reeh, PW. TRPA1 and Substance P Mediate Colitis in Mice. Gastroenterology, 141(4), pp. 1346-1358, 2011.
• Neacsu C, Ciobanu C, Barbu I, Toader O, Szegli G, Kerek F, Babes A. . Substance MCS-18 isolated from Helleborus purpurascens is a potent antagonist of the capsaicin receptor, TRPV1, in rat cultured sensory neurons. . Physiol Res. , 59(2), pp. 289-98, 2010.
• Neacsu C, Babes A. . The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1. J Pharmacol Sci. , 114(3), pp. 332-40, 2010.
• Babes A, Fischer MJ, Reid G, Sauer SK, Zimmermann K, Reeh PW. Electrophysiological and neurochemical techniques to investigate sensory neurons in analgesia research. Methods in Molecular Biology, 617, pp. 237-259, 2010.
• Ciobanu C, Reid G, Babes A. Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal root ganglion neurons. Brain Research, 1284, pp. 54-67, 2009.
• Leffler A, Linte RM, Nau C, Reeh P, Babes A. A high-threshold heat-activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium. European Journal of Neuroscience, 26(1), pp. 12-22, 2007.
• Linte, R. M., Ciobanu, C., Reid, G., Babes, A. Desensitization of cold- and menthol-sensitive rat dorsal root ganglion neurones by inflammatory mediators. Experimental Brain Research, 178, pp. 89-98, 2007.
• Zimmermann, K., Leffler, A., Babes, A., Cendan, C. M., Carr, R. W., Kobayashi, J., Nau, C., Wood, J. N., Reeh, P. Sensory neuron sodium channel Nav1. 8 is essential for pain at low temperatures. Nature, 447, pp. 855-859, 2007.

Publications from the ISI database, indexed between 2002-2011, produced in Romania:
• Babes, A; Lorinczi, E; Ristoiu, V; Flonta, ML; Reid, G, Slowed inactivation at positive potentials in a rat axonal K+ channel is not due to preferential closed-state inactivation. PHYSIOLOGICAL RESEARCH, 50 (6), pp. 557-565, 2001.
• Babes, A; Amuzescu, B; Krause, U; Scholz, A; Flonta, ML; Reid, G, Cooling inhibits capsaicin-induced currents in cultured rat dorsal root ganglion neurones. NEUROSCIENCE LETTERS, 317 (3), pp. 131-134, 2002.
• Reid, G; Babes, A; Pluteanu, F; Flonta, ML, Nerve growth factor sensitises the cold- and menthol-activated current in thermoreceptive neurones. JOURNAL OF PHYSIOLOGY-LONDON, 543, pp. 111P-112P, 2002.
• Babes, A; Flonta, ML; Reid, G, Cooling-sensitive neurones from rat dorsal root ganglia express a distinct repertoire of voltage-gated currents. JOURNAL OF PHYSIOLOGY-LONDON, 543, p. 115P, 2002.
• Reid, G; Babes, A; Pluteanu, F, A cold- and menthol-activated current in rat dorsal root ganglion neurones: properties and role in cold transduction. JOURNAL OF PHYSIOLOGY-LONDON, 545 (2), pp. 595-614, 2002.
• Babes, A; Zorzon, D; Reid, G, Two populations of cold-sensitive neurons in rat dorsal root ganglia and their modulation by nerve growth factor. EUROPEAN JOURNAL OF NEUROSCIENCE, 20 (9), pp. 2276-2282, 2004.
• Babes, A; Zorzon, D; Reid, G, A novel type of cold-sensitive neuron in rat dorsal root ganglia with rapid adaptation to cooling stimuli. EUROPEAN JOURNAL OF NEUROSCIENCE, 24 (3), pp. 691-698, 2006.
• Leffler, A; Linte, RM; Nau, C; Reeh, P; Babes, A, A high-threshold heat-activated channel in cultured rat dorsal root ganglion neurons resembles TRPV2 and is blocked by gadolinium. EUROPEAN JOURNAL OF NEUROSCIENCE, 26 (1), pp. 12-22, 2007.
• Zimmermann, K; Leffler, A; Babes, A; Cendan, CM; Carr, RW; Kobayashi, J; Nau, C; Wood, JN; Reeh, PW, Sensory neuron sodium channel Na(v)1.8 is essential for pain at low temperatures. NATURE, 447 (7146), pp. 855-858, 2007.
• Linte, RM; Ciobanu, C; Reid, G; Babes, A, Desensitization of cold- and menthol-sensitive rat dorsal root ganglion neurones by inflammatory mediators. EXPERIMENTAL BRAIN RESEARCH, 178 (1), pp. 89-98, 2007.
• Ciobanu, C; Reid, G; Babes, A, Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal root ganglion neurons. BRAIN RESEARCH, 1284, pp. 54-67, 2009.
• Neacsu, C; Ciobanu, C; Barbu, I; Toader, O; Szegli, G; Kerek, F; Babes, A, Substance MCS-18 Isolated from Helleborus Purpurascens Is a Potent Antagonist of the Capsaicin Receptor, TRPV1, in Rat Cultured Sensory Neurons. PHYSIOLOGICAL RESEARCH, 59 (2), pp. 289-298, 2010.
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