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Marilena Plesu (Lupu)

Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR 7284, Nice, Franța

Pagina web a instituției: http://ircan.org
Pagina web personală: http://www.researcherid.com/rid/A-4596-2011
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Născut(ă) în 1977

Interese: angiogeneza normala si patologica, modulare transcriptionala, terapie anti-angiogenica, biologia transplantului, plasticitatea celulelor stem, terapie celulara, transplant de celule stem hematopoietice, oncologie comparata, medicina translationala

Detalii:
Cercetarile curente ale Marilenei Plesu sunt focalizate pe investigarea implicarii unor molecule pro-(limf)angiogenice in dobandirea proprietatilor metastatice ca urmare a terapiei anti-angiogenice. Cercetarile sale precedente s-au axat pe variate aspecte ale biologiei celulelor stem si progenitoare adulte, terapiei celulare pentru regenerarea vasculara, biologiei transplantului, testarii histocompatibilitatii, preventiei si tratamentului bolii grefa-contra-gazda, precum si ale transplantului de celule hematopoietice pentru tratamentul hemopatiilor maligne si al distrofiei musculare Duchenne.


Experienta profesionala

2015 Marie Curie research fellow, Echipa "Angiogeneza Normala si Patologica", Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR 7284, Nice, France

2007-2013 Cercetator, Investigator Principal, Conducator de grup, Grupul "Angiogeneza si Remodelare Cardiovasculara", Departamentul de Medicina Regenerativa, Institutul de Biologie si Patologie Celulara "Nicolae Simionescu" al Academiei Romane, Bucuresti, Romania

2006-2007 Oncology fellow, Colegiul de Medicina Veterinara, Oregon State University, Corvallis, OR, USA

2004-2006 Doctorand/Postdoctoral fellow, Departamentul de Biologie a Transplantului, Laboratorul Storb, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

2002-2004 Doctorand cu frecventa, Departamentul de Oncologie Comparata si Laboratorul Clinic, Facultatea de Medicina Veterinara, Bucuresti, Romania

2003 Training in medicina transfuzionala si transplant autolog de celule hematopoietice, Departmentul de Transfuziologie si Transplant Medular, Institutul Clinic Fundeni, Bucuresti, Romania

2003 Training in transplant alogenic de celule hematopoietice, Sectia de Afereza a Celulelor Stem, Labortaorul de Procesare a Celulelor Stem si Sectia de Transplant Medular, Spitalul Szent László, Budapesta, Ungaria; Laboratorul de Tipizare HLA, Institutul National de Hematologie, Budapesta, Ungaria

1999-2001 Practica de vara in studiul biologiei cancerului, Departamentul de Biologie a Cancerului, Institutul Oncologic Prof. dr. Alexandru Trestioreanu, Bucuresti, Romania


Granturi

- Director de proiect - Grant PNCDI-II pentru stimularea formarii de tinere echipe de cercetare independente, finantat de catre Ministerul Educatiei si Cercetarii din Romania: "Investigarea mecanismelor moleculare ale integrarii si vasculogenezei aferente celulelor stem umane derivate din cordonul ombilical; implicatii pentru regenerarea cardiovasculara, acronim “RE-CORD”"; Perioada de derulare: 2010-2013;

- Partener si Coordonator stiintific in Grant FP7 "Capacitati" - Cooperare Internationala finantat de catre Comisia Europeana (Research Potential REGPOT-2009-2): "Reinforcement of the Adult stem cell research area through Mobility and Scientific networking between Egypt, Romania and a German consortium for Strengthening the international scientific competency", acronim "RAMSES"; Perioada de derulare: 2010-2013;

- Director de proiect - Grant de cooperare bilaterala Romano-Germana finantat de catre Ministerele Educatiei si Cercetarii din Romania si Germania: "Cooperare Bilaterala intre Romania si Germania pentru fortificarea competitivitatii stiintifice Europene in domeniul cercetarii celulelor stem cu aplicatii in regenerarea cardio-vasculara", acronim "CORES"; Perioada de derulare: 2009-2010;

- Director de proiect - Grant de reintegrare FP7 Marie Curie finantat de catre Comisia Europeana - Suport pentru dezvoltarea carierei (People 2007-4-3-IRG): "Terapia celulara cu celule progenitoare endoteliale pentru tratamentul ischemiei cardiace induse experimental", acronim "EPETER"; Perioada de derulare: 2008-2010;

- Director de proiect - Grant de reintegrare PNCDI-II finantat de catre Ministerul Educatiei si Cercetarii din Romania: "Dezvoltarea terapiilor celulare cu ajutorul celulelor progenitoare endoteliale derivate de la nivelul maduvei osoase si placentei umane"; Perioada de derulare: 2008-2010.


Distinctii

2006 Distinctia "Magna Cum Laude" pentru cercetarile doctorale oferita de catre Ministerul Educatiei si Cercetarii/Universitatea de Stiinte Agronomice si Medicina Veterinara, Bucuresti, Romania

2004-2006 Bursa in Oncologie si Biologia Transplantului oferita de catre National Institutes of Health, Bethesda, MD, USA

2003 Diploma de onoare "Carol Davila" pentru activitatea de cercetare in domeniul Oncologiei Comparate oferita de catre Facultatea de Medicina Veterinara, Bucuresti, Romania


Asociatii profesionale

2007 Membru - Sigma Xi, Societatea pentru Cercetare Stiintifica
2007 Membru - Asociatia Ad Astra - Proiect online pentru comunitatea stiintifica romaneasca
2006 Membru - American Association for the Advancement of Science
2005 Membru - American Society of Hematology
2005 Membru - Veterinary Cancer Society
1999 Membru - Societatea Romana de Oncologie Comparata

ResearcherID: A-4596-2011

Publicații relevante:
• Maria Cristina Corotchi, Mirel Adrian Popa, Anca Remes, Livia Elena Sima, Ilinca Gussi and Marilena Lupu Plesu. Isolation method and xeno-free culture conditions influence multipotent differentiation capacity of human Wharton' s jelly-derived mesenchymal stem cells. Stem Cell Research & Therapy, 4:81, 2013.
• Lupu. M, Khalil M., Andrei E., Iordache F., Hescheler J. Cardiac integration and vasculogenic properties of human umbilical cord blood- and Wharton's jelly-derived progenitor cells . In Proceedings: pp. 80-81, 1st Annual Cambridge Stem Cell Symposium: Pluripotency and Development, Cambridge, July 6-7. 2011.
• Lupu M., Khalil M., Andrei E., Iordache F., Pfannkuche K., Neef K., Georgescu A., Buzila C., Brockmeier K., Maniu H., Hescheler J . Integration Properties of Wharton’s Jelly-derived Novel Mesenchymal Stem Cells into Ventricular Slices of Murine Hearts. Cellular Physiology and Biochemistry , 28(1), pp. 63-76, 2011.
• Lupu M., Khalil M., Iordache F., Andrei E., Pfannkuche K., Spitkovsky D., Baumgartner S., Rubach M., AbdelRazek H., Buzila C., Brockmeier K., Simionescu M., Hescheler J., Maniu H. Direct Contact of Umbilical Cord Blood Endothelial Progenitors with Living Cardiac Tissue is a Requirement for Vascular Tube-like Structures Formation. Journal of Cellular and Molecular Medicine, 15(9), pp. 1914-26, 2011.
• Lupu M., Buzila C., Andrei E., Iordache F., Maniu H. Characterization of human umbilical cord blood- and Wharton’s jelly-derived endothelial progenitors for use in cellular therapy. In Proceedings: pp. 27, Adult somatic stem cells: new perspectives, Monaco, November 26-28. 2009.
• Lupu M., Andrei E., Iordache F., Grigorescu G., Buzila C., Maniu H. In vitro angiogenic potential of endothelial progenitors isolated from human Wharton's Jelly. In Proceedings: pp. S225, World Conference on regenerative medicine, Lipzig, Germany, October 29-31. 2009.
• Lupu M., Andrei E., Iordache F., Grigorescu G., Buzila C., Maniu H. Isolation and characterization of endothelial progenitor cells from human Wharton’s jelly. In Proceedings: pp. 68, IGB Meeting, Stem Cells: From Molecular Physiology to Therapeutic Applications, Capri, Italy, October 10-13. 2009.
• Helfand S. C., Lupu M. . Hematopoietic Cytokines: The Interleukin Array. In Bonagura J. D., Twedt D. C. (eds.), Evolve Resources for Kirk’s Current Veterinary Therapy XIV . Saunders, Elsevier , 2009.
• Lupu M., Andrei E., Buzila C., Constantinescu E., Georgescu A., Maniu H. Characterization of human umbilical cord blood-derived endothelial progenitors for use in cellular therapy. In Proceedings: pp. 42, Hydra IV: European Summer School – Stem Cells & Regenerative Medicine, Hydra, Greece, September 5-11. 2008.
• Lupu M, Gooley T, Zellmer E, Graves SS, Storb R. Principles of peripheral blood mononuclear cell apheresis in a preclinical canine model of hematopoietic cell transplantation. Journal of Veterinary Internal Medicine, Jan-Feb;22(1), pp. 74-82, 2008.
• Lupu M. *, Kuhr C. S. *, Storb R. (*equal contribution). Hematopoietic Cell Transplantation Directly into Dystrophic Muscle Fails to Reconstitute Satellite Cells and Myofibers. Biology of Blood and Marrow Transplantation, Aug;13(8), pp. 886-888, 2007.
• Lupu M., Storb R. Five decades of progress in haematopoietic cell transplantation based on the preclinical canine model. Veterinary and Comparative Oncology, 5 (1), pp. 14-3, 2007.
• Lupu M., Kuhr C. S., Storb R. Hematopoietic stem cells neither reconstitute satellite cells nor myofibers after direct injection into dystrophic muscle - Poster Session. In Proceedings, American Society of Hematology 48th Annual Meeting and Exposition, Orlando, FL, USA, December 9-12. 2006.
• Lupu M., Gooley T., Zellmer E., Storb R. Peripheral blood mononuclear cell apheresis in the canine model of hematopoietic cell transplantation: analysis of donor and apheresis related variables in 120 dogs - Oral presentation. In Proceedings, The 26th Annual Conf. of the Veterinary Cancer Society, Callaway Gardens, GA, USA, October 19-22. 2006.
• Lupu M., Kuhr C. S., Tapscott S., Storb R. Hematopoietic stem cells do not reconstitute satellite cells nor myofibers in hematopoietic canine chimeras with X-linked muscular dystrophy - Invited paper - Oral presentation. In Modiano J. F. (ed.), Genes, Dogs and Cancer: Fourth Annual Canine Cancer Conference, Sept. 14-17, Chicago, IL, USA. International Veterinary Information Service, Ithaca NY (www. ivis. org), Last updated: 17-Sep-2006; P4043. 0906, 2006.
• Lupu M., McCune J. S., Kuhr C. S., Gooley T., Storb R. Pharmacokinetics of oral mycophenolate mofetil in dog: bioavailability studies and the impact of antibiotic therapy. Biology of blood and marrow transplantation, Dec;12(12), pp. 1352-4, 2006.
• Kuhr C. S., Lupu M., Little M. -T., Zellmer E., Sale G. E., Storb R. RDP58 does not prevent graft-versus-host disease after dog leukocyte antigen-nonidentical canine hematopoietic cell transplantation. Transplantation, May 27;81(10), pp. 1460-2, 2006.
• Lupu M., Sullivan E. W., Westfall T. E., Little M. -T., Weigler B. J., Moore P. F., Stroup P. A., Zellmer E., Kuhr C. S., Storb R. Use of multigeneration-family molecular dog leukocyte antigen typing to select a hematopoietic cell transplant donor for a dog with T-cell lymphoma. Journal of the American Veterinary Medical Association, Mar; 228(5), pp. 1728-32, 2006.
• Lupu M., Sullivan E., Westfall T., Weigler B., Stroup P., Zellmer E., Kuhr C. S., Storb R. Multi-generation family molecular dog leukocyte antigen (DLA) typing to select a hematopoietic cell transplant donor for the treatment of a dog with spontaneous T-cell lymphoma - Oral presentation. In Proceedings, The 30th Congress of the World Small Animal Veterinary Association, Mexico City, Mexico, May 11-14. 2005.
• Cringanu D., Tanase A., Birtoiu A., Preda C., Lupu M., Cringanu I. Chemo-hormone-immunotherapy for mammary tumors in dog. Romanian Journal of Comparative Oncology, 7, pp. 471-84, 2003.
• Lupu M. Aspects of the cytological and histological correlative diagnosis in the veterinary medical practice - Oral presentation. In Proceedings: Vol. Nat. Conf. Onc. OC3, pp. 176, The National Conference of Oncology. Institute of Oncology Prof. Dr. Al. Trestioreanu, Bucharest. 2001.
• Lupu M. Aspects of the cytological and histological correlative diagnosis in the veterinary medical practice. Romanian Journal of Comparative Oncology, 4, pp. 300-11, 2001.

Teze și dizertații:
• Lupu M. PhD Dissertation (" Magna Cum Laude" ): Clinical and Experimental Studies of Hematopoietic Cell Transplantation in Dogs. 2006.

Publicații din baza de date ISI, indexate în 2002-2011, realizate în România:
• Iordache, F; Iordache, C; Pop, A; Lupu, M; Andrei, E; Buzila, C; Maniu, H, Effects of plant lectin and extracts on adhesion molecules of endothelial progenitors. CENTRAL EUROPEAN JOURNAL OF BIOLOGY, 6 (3), pp. 330-341, 2011.
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