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Marilena Plesu (Lupu)

Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR 7284, Nice, France

Institution web page: http://ircan.org
Personal web page: http://www.researcherid.com/rid/A-4596-2011
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Born: 1977

Interests: normal and pathological angiogenesis, transcriptional regulation, anti-angiogenic therapy, transplantation biology, stem cell plasticity, cell therapy, hematopoietic stem cell transplantation, comparative oncology, translational research

Details:
Marilena Plesu’s current research is focused on the investigation of pro-(lymph)angiogenic cytokines involvement into the aquired metastatic properties following various anti-angiogenic treatments, and validation of reliable anti-angiogenic therapeutic tools. Her previous studies have addressed various aspects of adult stem cells and progenitor cells biology, cell therapy for vascular repair and regeneration, transplantation biology, histocompatibility testing, graft-versus-host disease prevention and treatment, and hematopoietic cell transplantation for the treatment of hematological malignancies and Duchenne muscular dystrophy.


Professional experience

2015 Marie Curie Research Fellow, "Normal and Pathological Angiogenesis" Team, Institute for Research on Cancer and Aging, Nice (IRCAN), CNRS UMR 7284, Nice, France

2007-2013 Scientist, Principal Investigator, Group Leader, "Angiogenesis and Cardiovascular Remodeling" Group, Regenerative Medicine Department, Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, Bucharest, Romania

2006-2007 Oncology Fellow, College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA

2004-2006 Ph.D. Student/Postdoctoral Fellow, Clinical Research Division - Transplantation Biology Program, Storb's Laboratory, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

2002-2004 Ph.D. Student, Comparative Oncology Department and Teaching Hospital Clinical Laboratory, School of Veterinary Medicine, Bucharest, Romania

2003 Visiting Trainee - Training in Transfusion Medicine and Autologous Hematopoietic Cell Transplantation, Department of Blood Transfusion and Bone Marrow Transplantation, Clinical Institute “Fundeni“, Bucharest, Romania

2003 Visiting Trainee - Training in Allogeneic Hematopoietic Cell Transplantation, Stem Cell Aphaeresis Unit, Stem Cell Laboratory and Bone Marrow Transplantation Unit, “Szent László” Hospital, Budapest, Hungary; The HLA-Typing Laboratory, National Institute of Hematology, Budapest, Hungary

1999-2001 Volunteer research internships in Cancer Biology, Cancer Biology Department, Institute of Oncology “Prof. Dr. Al. Trestioreanu”, Bucharest, Romania


Grants

- Experienced researcher - FP7 Marie Curie Grant from the European Commission - (FP7-PEOPLE-2013-IEF): "Investigation of VEGF-C involvement in the acquired metastatic properties of renal cell carcinoma following anti-angiogenesis treatments", acronym “VELYMPH”; Duration: 2015-2016;

- Principal investigator - Swiss-Romanian Bilateral Cooperation Grant funded by the Swiss National Science Foundation/Romanian Ministry of Education and Research: “Effects of sex steroids on adult stem/progenitor cell-mediated cardiovascular regeneration”; Duration: 2013-2015;

- Principal investigator - Partnership Grant funded by the Romanian Ministry of Education and Research: “Preclinical model of cell therapy employing protein tyrosine phosphatase-microRNA interplay to optimize neovascularization”, acronym "THERION"; Duration: 2012-2015;

- Principal investigator, Project coordinator - PNCDI-II Grant for the development of a young research team, granted by the Romanian Ministry of Education and Research: "Molecular mechanisms of human umbilical cord-derived stem cells integration and vasculogenesis within the cardiac tissue; implications for cardiovascular regeneration”, acronym “RE-CORD”; Duration: 2010-2013;

- Partner and Scientific coordinator in FP7 Capacities - International Cooperation Grant from the European Commission (Research Potential REGPOT-2009-2): “Reinforcement of the Adult stem cell research area through Mobility and Scientific networking between Egypt, Romania and a German consortium for Strengthening the international scientific competency”, acronym “RAMSES”; Duration: 2010-2013;

- Principal investigator, Project coordinator - German-Romanian Bilateral Cooperation Grant funded by the Romanian Ministry of Education and Research and the Federal Ministry of Education and Research from Germany: “Bilateral cooperation between Romania and Germany for reinforcing the European scientific competitiveness in the field of stem cell research with applications for cardiovascular regeneration”, acronym “CORES”; Duration: 2009-2010;

- Principal investigator - FP7 Marie Curie International Reintegration Grant from the European Commission - Support for training and career development of researchers (People 2007-4-3-IRG): "Cell therapy employing endothelial progenitors for experimentally induced cardiac ischemia", acronym “EPETER”; Duration: 2008-2010;

- Principal investigator, Project coordinator - PNCDI-II Reintegration Grant from the Romanian Ministry of Education and Research: "Development of cell therapies using endothelial progenitors derived from human bone marrow and placental tissues"; Duration: 2008-2010.


Honors and awards

2006 "Magna Cum Laude" distinction for PhD thesis research from the Ministry of Education and Research/University of Agronomical Sciences and Veterinary Medicine, Bucharest, Romania

2004-2006 Fellowship in Oncology and Transplantation Biology from the National Institutes of Health, Bethesda MD, USA

2003 “Carol Davila” Honor Diploma for research activity in Veterinary and Comparative Oncology from the School of Veterinary Medicine, Bucharest, Romania


Professional memberships

2007 Member of Sigma Xi - The Scientific Research Society
2007 Member of Ad Astra Association - An Online Project for the Romanian Scientific Community
2006 Member of the American Association for the Advancement of Science
2005 Member of the American Society of Hematology
2005 Member of the Veterinary Cancer Society
1999 Member of the Romanian Society of Comparative Oncology

ResearcherID: A-4596-2011

Selected publications:
• Maria Cristina Corotchi, Mirel Adrian Popa, Anca Remes, Livia Elena Sima, Ilinca Gussi and Marilena Lupu Plesu. Isolation method and xeno-free culture conditions influence multipotent differentiation capacity of human Wharton' s jelly-derived mesenchymal stem cells. Stem Cell Research & Therapy, 4:81, 2013.
• Lupu. M, Khalil M., Andrei E., Iordache F., Hescheler J. Cardiac integration and vasculogenic properties of human umbilical cord blood- and Wharton's jelly-derived progenitor cells . In Proceedings: pp. 80-81, 1st Annual Cambridge Stem Cell Symposium: Pluripotency and Development, Cambridge, July 6-7. 2011.
• Lupu M., Khalil M., Andrei E., Iordache F., Pfannkuche K., Neef K., Georgescu A., Buzila C., Brockmeier K., Maniu H., Hescheler J . Integration Properties of Wharton’s Jelly-derived Novel Mesenchymal Stem Cells into Ventricular Slices of Murine Hearts. Cellular Physiology and Biochemistry , 28(1), pp. 63-76, 2011.
• Lupu M., Khalil M., Iordache F., Andrei E., Pfannkuche K., Spitkovsky D., Baumgartner S., Rubach M., AbdelRazek H., Buzila C., Brockmeier K., Simionescu M., Hescheler J., Maniu H. Direct Contact of Umbilical Cord Blood Endothelial Progenitors with Living Cardiac Tissue is a Requirement for Vascular Tube-like Structures Formation. Journal of Cellular and Molecular Medicine, 15(9), pp. 1914-26, 2011.
• Lupu M., Buzila C., Andrei E., Iordache F., Maniu H. Characterization of human umbilical cord blood- and Wharton’s jelly-derived endothelial progenitors for use in cellular therapy. In Proceedings: pp. 27, Adult somatic stem cells: new perspectives, Monaco, November 26-28. 2009.
• Lupu M., Andrei E., Iordache F., Grigorescu G., Buzila C., Maniu H. In vitro angiogenic potential of endothelial progenitors isolated from human Wharton's Jelly. In Proceedings: pp. S225, World Conference on regenerative medicine, Lipzig, Germany, October 29-31. 2009.
• Lupu M., Andrei E., Iordache F., Grigorescu G., Buzila C., Maniu H. Isolation and characterization of endothelial progenitor cells from human Wharton’s jelly. In Proceedings: pp. 68, IGB Meeting, Stem Cells: From Molecular Physiology to Therapeutic Applications, Capri, Italy, October 10-13. 2009.
• Helfand S. C., Lupu M. . Hematopoietic Cytokines: The Interleukin Array. In Bonagura J. D., Twedt D. C. (eds.), Evolve Resources for Kirk’s Current Veterinary Therapy XIV . Saunders, Elsevier , 2009.
• Lupu M., Andrei E., Buzila C., Constantinescu E., Georgescu A., Maniu H. Characterization of human umbilical cord blood-derived endothelial progenitors for use in cellular therapy. In Proceedings: pp. 42, Hydra IV: European Summer School – Stem Cells & Regenerative Medicine, Hydra, Greece, September 5-11. 2008.
• Lupu M, Gooley T, Zellmer E, Graves SS, Storb R. Principles of peripheral blood mononuclear cell apheresis in a preclinical canine model of hematopoietic cell transplantation. Journal of Veterinary Internal Medicine, Jan-Feb;22(1), pp. 74-82, 2008.
• Lupu M. *, Kuhr C. S. *, Storb R. (*equal contribution). Hematopoietic Cell Transplantation Directly into Dystrophic Muscle Fails to Reconstitute Satellite Cells and Myofibers. Biology of Blood and Marrow Transplantation, Aug;13(8), pp. 886-888, 2007.
• Lupu M., Storb R. Five decades of progress in haematopoietic cell transplantation based on the preclinical canine model. Veterinary and Comparative Oncology, 5 (1), pp. 14-3, 2007.
• Lupu M., Kuhr C. S., Storb R. Hematopoietic stem cells neither reconstitute satellite cells nor myofibers after direct injection into dystrophic muscle - Poster Session. In Proceedings, American Society of Hematology 48th Annual Meeting and Exposition, Orlando, FL, USA, December 9-12. 2006.
• Lupu M., Gooley T., Zellmer E., Storb R. Peripheral blood mononuclear cell apheresis in the canine model of hematopoietic cell transplantation: analysis of donor and apheresis related variables in 120 dogs - Oral presentation. In Proceedings, The 26th Annual Conf. of the Veterinary Cancer Society, Callaway Gardens, GA, USA, October 19-22. 2006.
• Lupu M., Kuhr C. S., Tapscott S., Storb R. Hematopoietic stem cells do not reconstitute satellite cells nor myofibers in hematopoietic canine chimeras with X-linked muscular dystrophy - Invited paper - Oral presentation. In Modiano J. F. (ed.), Genes, Dogs and Cancer: Fourth Annual Canine Cancer Conference, Sept. 14-17, Chicago, IL, USA. International Veterinary Information Service, Ithaca NY (www. ivis. org), Last updated: 17-Sep-2006; P4043. 0906, 2006.
• Lupu M., McCune J. S., Kuhr C. S., Gooley T., Storb R. Pharmacokinetics of oral mycophenolate mofetil in dog: bioavailability studies and the impact of antibiotic therapy. Biology of blood and marrow transplantation, Dec;12(12), pp. 1352-4, 2006.
• Kuhr C. S., Lupu M., Little M. -T., Zellmer E., Sale G. E., Storb R. RDP58 does not prevent graft-versus-host disease after dog leukocyte antigen-nonidentical canine hematopoietic cell transplantation. Transplantation, May 27;81(10), pp. 1460-2, 2006.
• Lupu M., Sullivan E. W., Westfall T. E., Little M. -T., Weigler B. J., Moore P. F., Stroup P. A., Zellmer E., Kuhr C. S., Storb R. Use of multigeneration-family molecular dog leukocyte antigen typing to select a hematopoietic cell transplant donor for a dog with T-cell lymphoma. Journal of the American Veterinary Medical Association, Mar; 228(5), pp. 1728-32, 2006.
• Lupu M., Sullivan E., Westfall T., Weigler B., Stroup P., Zellmer E., Kuhr C. S., Storb R. Multi-generation family molecular dog leukocyte antigen (DLA) typing to select a hematopoietic cell transplant donor for the treatment of a dog with spontaneous T-cell lymphoma - Oral presentation. In Proceedings, The 30th Congress of the World Small Animal Veterinary Association, Mexico City, Mexico, May 11-14. 2005.
• Cringanu D., Tanase A., Birtoiu A., Preda C., Lupu M., Cringanu I. Chemo-hormone-immunotherapy for mammary tumors in dog. Romanian Journal of Comparative Oncology, 7, pp. 471-84, 2003.
• Lupu M. Aspects of the cytological and histological correlative diagnosis in the veterinary medical practice - Oral presentation. In Proceedings: Vol. Nat. Conf. Onc. OC3, pp. 176, The National Conference of Oncology. Institute of Oncology Prof. Dr. Al. Trestioreanu, Bucharest. 2001.
• Lupu M. Aspects of the cytological and histological correlative diagnosis in the veterinary medical practice. Romanian Journal of Comparative Oncology, 4, pp. 300-11, 2001.

Theses and dissertations:
• Lupu M. PhD Dissertation (" Magna Cum Laude" ): Clinical and Experimental Studies of Hematopoietic Cell Transplantation in Dogs. 2006.

Publications from the ISI database, indexed between 2002-2011, produced in Romania:
• Iordache, F; Iordache, C; Pop, A; Lupu, M; Andrei, E; Buzila, C; Maniu, H, Effects of plant lectin and extracts on adhesion molecules of endothelial progenitors. CENTRAL EUROPEAN JOURNAL OF BIOLOGY, 6 (3), pp. 330-341, 2011.
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