
Marcel O. Vlad, Alexandru Dan Corlan, Vlad T. Popa, John Ross. On antiportfolio effects in science and technology with application to reaction kinetics, chemical synthesis, and molecular biology. PNAS, 104, pp. 183981840, 2007.
Abstract:
The portfolio effect is the increase of the stability of a system to random fluctuations with the increase of the number of random state variables due to spreading the risk among these variables; many examples exist in various areas of science and technology. We report the existence of an opposite effect, the decrease of stability to random fluctuations due to an increase of the number of random state variables. For successive industrial or biochemical processes of independent, random efficiencies, the stability of the total efficiency decreases with the increase of the number of processes. Depending on the variables considered, the same process may display both a portfolio as well as an antiportfolio behavior. In disordered kinetics, the activation energy of a reaction or transport process is the result of a sum of random components. Although the total activation energy displays a portfolio effect, the rate coefficient displays an antiportfolio effect. For randomchannel kinetics, the stability of the total rate coefficient increases with the average number of reaction pathways, whereas the stability of the survival function has an opposite behavior: it decreases exponentially with the increase of the average number of reaction pathways (antiportfolio effect). In molecular biology, the total rate of a nucleotide substitution displays a portfolio effect, whereas the probability that no substitutions occur displays an antiportfolio effect, resulting in faster evolutionary processes due to fluctuations. The antiportfolio effect emerges for products of random variables or equations involving multiplicative convolution products.
Keywords:
disordered kinetics, molecular biology clocks, molecular evolution, multiplicative random variables, random fields
URL:
http://www.pnas.org/cgi/content/abstract/0708624104v1
Posted by
Alexandru Dan Corlan
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