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Ciobanu LC, Maltais R, Poirier D. . The sulfamate functional group as a new anchor for solid-phase organic synthesis. Organic Letters, Feb 24 2(4), pp. 445-448, 2000.

Abstract: Sulfamate derivatives were loaded on trityl chloride resin, and two variants of cleavage were developed for this sulfamate anchor: an acid treatment to easily restore the free sulfamate and a nucleophilic treatment to generate the corresponding phenol. In addition to loading/cleavage assays and stability experiments, a model sequence of reactions was performed with the new sulfamate anchor to show its applicability in further combinatorial solid-phase synthesis of libraries of biologically relevant sulfamate derivatives.

Keywords: sulfamate, solid phase organic synthesis

Posted by Liviu Constantin Ciobanu


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