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Aurelian UdristioiučManole Cojocaru. Risk of Dis-lipids Syndrome in Modern Society. , 2016.

Rezumat: Introduction
Dis-lipids, (low density lipoproteins), hyper-triglyceride status means in principal high concentration of VLDL, (very low lipoproteins) an VLDL increased, seldom IDL.
Scope syndromes are the metabolic statuses with contain qualitative and quantitative modifies of lipoproteins. Hyper-cholesterol isolate status means in principal high concentration of fraction LDL
The aim of this work was to emphasis the preclinical evaluation of dis-lipids syndromes types at the un-treated patients for any disease, which were presented to a routine control for checking health status in ambulatory.
Material and Method:
Were analyzed 60 patients, registered in Clinical Laboratory, assessing by running on the Hitachi 912 Analyzer, the principal biochemical parameters of lipid metabolism: Cholesterol, Triglycerides and fractions of Cholesterol, HDL and LDL. From the total of 60 patients 35 were females and 25 males. Mean age for females was 27-45 years for female and 37-52 years for males. All patients have not been in evidence with known cardiovascular, chronic metabolic or endocrine diseases. All our results obtained were in validation after was accomplished calibrations, internal controls and reference interval established on 120 known apparent health patients, analyzed in clinical laboratory, on each parameter measured.
The persons with metabolic lipid health status, were registered in 23% percent, the patients which has presented isolate high LDL as an alarm signal of start on atherosclerotic process, were in 28 % percent, and persons with low HDL was in 17% percent. The cases with atherosclerotic index, Report-LDL/HDL>3.5 for men and 2.5 for women , were in 14 % percent, the cases with predictive value with coronary risk, Report-CO/HDL>5 were presented in 5 % percent and the cases with dis-lipid syndrome type 2- 4, with high Cholesterol and Triglycerides, were presented in in 30% percent.
Lipids controls, on fractions of Cholesterol, LDL, HDL, Triglyceri d seldom chylo-microns and hyper-lipids mixed syndromes mean together high LDL and des are necessary to be prevented atherosclerotic of incipient status of ill. Familial dis-lipids syndromes must be analyzed at young ages, to different, apparent health persons, with ages past 35 years.
Key words: low density lipoproteins, very low density lipoproteins, intermediate density lipoproteins, cholesterol, triglycerides, chylomicrons.

In the all developed countries, the numbers of obese persons, diagnosed with insulin resistance (IR) have increased rapidly to >40% in recent years. IR is a patho-physiological state characterized by a subnormal physiological response to insulin concentrations. This state precedes the development of metabolic syndrome (MS). Insulin resistance is often considered a pre-diabetic condition [1].
MS consists of multiple, interrelated risk factors of metabolic origin that appear to promote the development of atherosclerotic cardiovascular disease (ASCVD) and which are strongly associated with type 2 diabetes mellitus or the risk for this condition [2].
The metabolic risk factors consist of atherogenetic dyslipidemia (elevated triglycerides and apolipoprotein B, small LDL particles, low HDL cholesterol [HDL-C] concentrations), elevated blood pressure, elevated plasma glucose, a prothrombotic state, and a proinflammatory state [3].
The World Health Organization (WHO) has slightly different criteria for metabolic syndrome, including high insulin levels, elevated fasting blood glucose, or elevated post-meal glucose alone with at least two of the following criteria: abdominal obesity (defined as a waist-to-hip ratio greater than 0.9), a body mass index of ≥30 kg/m2 or a waist measurement >37 inches, a lipid panel showing a triglyceride level ≥150 mg/dl or an HDL cholesterol >35 mg/dl an blood pressure ≥ 140/90 (or receiving treatment for high blood pressure) [4].
Dis-lipids syndromes mean the metabolic statuses with qualitative and quantitative modifies of lipoproteins. Hyper-lipids syndromes means increases concentration of triglycerides and or cholesterol past acceptable limits in function of age, sex and health status. Hyper-cholesterol isolate status means high concentration of fraction low density lipoproteins (LDL), hyper-triglyceride status means high concentration of very low lipoproteins, (VLDL) and seldom chylo-microns and hyper-lipids mixed syndromes mean together high LDL and VLDL increased, seldom intermediate density lipoproteins (IIDL) [5], [Table 4].
Lack of receptors for LDL to fibroblasts cells and adipose cells will develop familial high-cholesterol with increases in serum of LDL-oxizing, together with cholesterol and triglycerides which will determine premature atherosclerosis [6], [Figure 1].
The rapport: Total Cholesterol/ HDL (high density lipoproteins) have the predictive value for coronary risk if its value is higher or equal with 5. The report LDL/ HDL, with predictive value past >3.5 for men and past>2.5 to women, mean atherosclerotic incipient index [7].
The diet and exercise combination presented in this study proved to be an effective treatment for MS, and this or a similar regimen should be recommended by physicians to patients who show signs of MS. For patients who show limited results from exercising on a stationary bicycle (or other exercising methods), drug treatment, such as specific treatment for dyslipid disorder, administration of leptins, leptin genes, or promoter drugs may be necessary, in addition to physical exercise and maintenance of an appropriate diet.

Cuvinte cheie: Key words: low density lipoproteins, very low density lipoproteins, intermediate density lipoproteins, cholesterol, triglycerides, chylomicrons.


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