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D. Popov. Mitochondrial stress in translational medicine toward metabolic diseases. Acta Endocrinologica (Buch) , XI, no. 3, pp. 269-275, 2015.

Abstract: The recent discoveries on organelles autoregulation and their molecular mechanisms motivate a novel perspective on mitochondria involvement in cardiovascular dysfunctions related to diabetes mellitus and obesity. We present here an up-dated view on the latter topic along with a condensed perception on morphological details resultant from diabetes mellitus experimental models. The article is organized into sections covering the following topics: (i) mitochondrial stress/dysfunction, (ii) the “quality controller” role of mitochondria exerted by fusion, fission, and mitophagy events, (iii) the connection between mitochondria and metabolic diseases, and (iv) the perspectives of potential application of mitochondrial-targeted compounds in metabolic diseases. Critical analysis of the knowledge available so far on mitochondria-metabolic diseases relationship allows a two sides conclusion: a doubtful view, as the correlation between impaired mitochondrial function and insulin resistance is still unclear, even after 40 years since its first publication, and an hopeful view based on the novel traits of this organelle uncovered recently, such as plasticity, the “quality controller” role, the “retrograde signaling”, and the coordinate interaction with nucleus, endoplasmic reticulum, Golgi apparatus and lysosomes. At the horizon, the essential issue of targeting mitochondria for the alleviation of diabetes/obesity complications remains to be resolved.

Keywords: oxidative stress, mitochondrial dynamics, fusion, fission, mitophagy


Posted by Doina Popov


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