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>> Românã

Doina Popov. Platelet mitochondrial function and dysfunction: physiological consequences . FISIOLOGíA. Boletín informativo de la SECF, 18(1), pp. 15-17, 2015.

Abstract: There is a general trend in revisiting mitochondria using the up-to-date technologies that uncovered novel attributes of this organelle,
such as the intracellular displacement to locations where an energy supply is needed, the dynamic shape changes and turnover, the
initiation of signaling to the rest of the cell, and the ability to crosstalk with other cellular organelles. The in-depth scrutiny of platelet
mitochondria role in health and pathology is included within this ongoing revisiting trend. The current article puts into a nutshell the most
recent data on platelet mitochondria function and disease-related malfunction, focusing on generation of stress- and apoptosis-related
signaling molecules, overproduction of reactive oxygen species during activation and disease, on the biomarker potential of platelets
mitochondria, and their prospective exploitation in translational applications. These novel findings complete the physiological profile of
platelets and could have potential therapeutic effectiveness in platelet-associated disorders.

Keywords: mitochondrial dynamics, blood storage, ROS


Posted by Doina Popov


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