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Eugenia DUMITRESCU, Viorica CHIURCIU, Florin MUSELIN, Roxana POPESCU, Diana BREZOVAN, Romeo T. CRISTINA. Effects of long-term exposure of female rats to low levels of lead: ovary and uterus histological architecture changes. Turkish Journal of Biology, 39(2), pp. 284-289, 2015.

Abstract: The aim of the current study was to evaluate lead accumulation in the ovaries, fallopian tubes, and uterus and to take note of any consequent histo-architectural changes. The experiment involved a 12-month chronic exposure of 28 Wistar female rats at
sexual maturity (221 0.88 g/ individual) to lead acetate in drinking water. The rats were divided into 4 groups based on the level
of lead exposure: E1 at 0.050 mg L1, E2 at 0.100 mg L1, E3 at 0.150 mg L1 , and a control group that received tap water. Lead level evaluation was performed by atomic absorption spectrometry at 283.3 nm and the histo-architectonics in target organs were evaluated after hematoxylin and eosin staining and microscopy. The exposure to lead acetate produced significant histological alterations caused by lead accumulation in the sexual organs. These structural changes correlated with the level of exposure in the ovaries, uterus, and fallopian tubes. They were mainly edemas and necrosis, denudation, and/or different stages of follicle evolution. These alterations have
been shown to indicate infertility in female rats.

Keywords: Histo-architecture, lead, rat model, reproductive toxicology


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