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Gabriela Carja, Yoshizaku Kameshima, Gabriela Ciobanu, Horia Chiriac, Kiyoshi Okada. New hybrid nanostructures based on oxacillin-hydrotalcite-like anionic clays and their textural properties. Micron , 40 (1), pp. 147-150 , 2009.

Abstract: New hybrid nanostructures based on inorganic matrices of hydrotalcite-like anionic clays (HT) incorporated with oxacillin are obtained by using calcinations-restructure method. XRD and TEM analyses are used to study the structural and textural characteristics of the clay containing hybrids. When nanoparticles of iron oxides are loaded on the layered anionic clay matrix a more effective delivery system of the drug is obtained. The results can be used to reduce the toxic side effects of oxacillin (e.g. upset stomach, diarrhea, cholestastic hepatitis), its aggregation process in aqueous solutions and also can open new perspectives for targeted the drug delivery.

Keywords: Oxacillin, Layered double hydroxides, Hydrotalcite, Drug delivery, TEM

Posted by Margareta Gabriela Ciobanu


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